background: our previous in vivo studies confirmed that icd-85, as an anticancer agent, was able to prevent further growth of breast tumors and expand the life expectancy of mice with breast cancer. methods: blood collection was carried out before, 1, 3, and 6 hours after icd-85 injection. sera were used to determinate the cardio and hepatic enzymes levels, including alt, ast, ldh, cpk, and ck-...

copper complexes of [cu(phen)(tda)].2h2o(1) and [(phen)2cu(µ-tda) cu(phen)](clo4)2.1.5h2o (2) (where phen is 1,10-phenanthroline and tda2- is thiodiacetate) have been synthesized. both complexes were characterized by elemental analysis, ir, uv–vis spectroscopy and cyclic voltammetry. their solid state structures were determined by the single crystal x-ray diffraction method. complex 1 is mononu...

results aβ (1-42) stimulated the production of the proinflammatory cytokines il6, il1β, tnfα, and il18 in both the primary microglia cell culture and the b92 cell line. both the raav-il4 construct and the ril-4 protein were found to inhibit production of the most important aβ (1-42)-induced proinflammatory cytokine mrnas in the two types of cells with different patterns. conclusions it seems th...

background: absent in melanoma 2 (aim2) is an intracellular microbial dsdna sensor which plays an important role in production of proinflammatory cytokines through apoptosis associated speck-like protein containing a caspase activation and recruitment domain (asc) and caspase-1. micro-rnas (mirnas) play important roles in regulation of immune related genes. however, there is little information ...

background: leishmania major is an intracellular parasite transmitted through the bite of the female phlebotomine sand flies. leishmania major is able to escape the host immune defense and survive within macrophages. modulation of the nf-κb (nuclear factor-kappa b) activation and suppression of the pro-inflammatory cytokines by l. major are the main evasion mechanisms that remain to be explored...

the formation of charge-transfer complexation between dibenzo-15-crown-5 (db15c5) and benzo-12-crown-4 (b12c4) (donor) and iodine is investigated spectrophotometrically in three chlorinated solvents,chloroform, dichloromethane (dcm) and 1,2-dichloroethane (dce) solution at 25°c. the change in polarityof the solvent also doesn’t affect the stoichiometry of the complexes. values of formation cons...

abstract background: primary cardiac lymphoma is extremely rare. case report: in this care report, we present the case of a 46-year-old man with primary cardiac lymphoma involving left atrium and interatrial septum, presenting as dyspnea palpitation and irregular heart beat. the diagnosis was obtained by transthoracic echocardiography and surgical biopsy with subxiphoid approach which revealed ...

we report herein the development of a highly sensitive colorimetric method for the detection of 4-hydroxy-2-mercapto-6-methylpyrimidine (mtu) which acts as an anti-thyroid drug utilizing citrate capped gold nanoparticles (au-nps). this thiol-containing molecule exhibits intriguing affinity with au-nps. the reactivity involves the displacement of the citrate shell by the thiolate shell followed ...