Voltage-gated sodium (NaV) channels are membrane proteins that consist of 24 transmembrane segments organized into four homologous domains, and are essential for action potential generation and propagation. Although the S6 helices of NaV channels line the ion conducting pore and participate in channel activation, their functional architecture is incompletely understood. Our recent studies show ...

Radial glial cells (RGCs) which function as neural stem cells are known to be non-excitable and their proliferation depends on the intracellular calcium (Ca2+) level. It has been well established that Inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release and Ca2+ entry through various Ca2+ channels are involved in the proliferation of RGCs. Furthermore, RGCs line the ventricular wall and are...

the purpose of this research is to numerically investigate the interaction of pulsatile flow of blood with an axisymmetric artery in various percentages of stenosis. the carreau non-newtonian model and the generalized maxwell rheological model were used to model the blood fluid and the viscoelastic wall of arterial, respectively. the innovation of the present research is modeling of viscoelasti...