PURPOSE This study investigated the trade-off in tumor coverage and organ-at-risk sparing when applying dose escalation for concurrent chemoradiation therapy (CRT) of mid-esophageal cancer, using radiobiological modeling to estimate local control and normal tissue toxicity. METHODS AND MATERIALS Twenty-one patients with mid-esophageal cancer were selected from the SCOPE1 database (Internation...

There is strong evidence that ionizing radiation increases cancer risks at high doses (e.g., >1 Gy), and persuasive, if controversial, epidemiological evidence that cancer risks are increased at low doses ( 10 mGy). Discussed here are the issues related to extrapolating radiation risks from low radiation doses to very low doses (<1 mGy) — for which purpose we are forced to rely on radiobiologic...

In this paper we shall concentrate on designing a mathematical model of the recombination and diffusion of the radicals formed when a radioactive particle passes through the cell. This process is described by a system of partial differential equation in three space dimension. We shall demonstrate how to transform this problem to one space variable and propose a method how to solve it. Introduct...

Radiotherapy techniques in the last decade evolved to the stage where the potential dose distribution significantly differs from earlier practices. Rotational IMRT, robotic radiotherapy or proton radiotherapy enables extremely precise dose delivery to target volumes, on the other hand, these techniques can yield a number of problems. As for photon radiotherapy, this concerns primarily the effec...

Recent developments in microbeam technology have made drastic improvements in particle delivery, focusing, image processing and precision to allow for rapid advances in our knowledge in radiation biology. The unequivocal demonstration that targeted cytoplasmic irradiation results in mutations in the nuclei of hit cells and the presence of non-targeted effects, all made possible using a charged ...