A series of organic cations, such as triphenylphosphonium (TPP), 2-(diphenylphosphoryl)-ethyldiphenylphosphonium (TPEP), represent molecular probes for imaging tumors. These organic cations have been labeled with ⁶⁴Cu radioisotope for imaging tumors by positron emission tomograghy (PET). Among these organic cation ligands, TPEP was selected for extensive evaluation using magnetic resonance imag...

Natural Cu target was irradiated with proton beam in the energy range of 15 to 30 MeV at a beam current of 100 μA for 15 min. In this irradiation radioisotope of 62Zn was produced as a generator and then decayed to Cu radioisotope. The Cu is emitting β+ and known as PET radioisotope. Excitation function of Cu via Cu (p, 2n) Zn, Cu and Cu (d, 3n) Zn reactions were calculated using Alice and Taly...

It has been alleged that radioisotope scanning of posterior fossa lesions is of little value (1-8) or at best, difficult (9,10) and frequently unrewarding (11). Some clinics even report the virtual abandonment of posterior fossa scanning (12,13). On the other hand, there are those who maintain that scanning of the posterior fossa is a worthwhile adjunct in the evaluation of lesions in that re g...

Radionuclide bone scanning has been a mainstay in the noninvasive evaluation of bone disease for decades. While SPECT imaging provides better evaluation of abnormal tracer uptake than planar scintigraphy, it still produces less than ideal anatomic localization. The introduction of hybrid SPECT/CT devices such as BrightView XCT has added value in improved localization of skeletal lesions and imp...

Abstract Objective The present study aimed to clarify the occurrence rate of lymphedema and prognosis in patients with endometrial cancer according sentinel lymph node biopsy alone intraoperative histopathological examination. Methods included 45 consecutive treated at Tohoku University Hospital between October 2014 August 2017. All had carcinoma endometrioid histology Grade 1 or 2 confirmed by...

We would like to propose floating dural sac sign, which is observed as a hyperintense band or rim around the spinal dural sac on axial T2-weighted images, as a sensitive sign to identify cerebrospinal fluid (CSF) leakage. One hundred patients with orthostatic headache were prospectively registered in 11 hospitals. These patients were examined by brain magnetic resonance (MR) imaging (n = 89), r...

Scandium-44 (t1/2 = 3.9 h) is a relatively new radioisotope of potential interest for use in clinical positron emission tomography (PET). Herein, we report, for the first time, the room-temperature radiolabeling of proteins with (44)Sc for in vivo PET imaging. For this purpose, the Fab fragment of Cetuximab, a monoclonal antibody that binds with high affinity to epidermal growth factor receptor...

OBJECTIVES Use of a positron emission tomography (PET)/single-photon emission computed tomography (SPECT) system facilitates the simultaneous acquisition of images with fluorine-18 fluorodeoxyglucose ((18)F-FDG) and technetium ((99m)Tc)-tetrofosmin. However, (18)F has a short half-life, and 511 keV Compton-scattered photons are detected in the (99m)Tc energy window. Therefore, in this study, we...

UNLABELLED Thrombus formation plays a major role in cardiovascular diseases, but noninvasive thrombus imaging is still challenging. Fibrin is a major component of both arterial and venous thrombi and represents an ideal candidate for imaging of thrombosis. Recently, we showed that (64)Cu-DOTA-labeled PET probes based on fibrin-specific peptides are suitable for thrombus imaging in vivo; however...