The article by Drs. Wasserman and Brizel concludes that protection of normal tissue from side effects due to radiotherapy will permit dose escalation and improve therapeutic efficacy and treatment outcomes. Although this concept is sound in principle, its generalized clinical application hinges critically on two controversial issues associated with the use of all putative radioprotective agents...

There has been a major progress in the area of radioprotective agents since the early 1980s in terms of biological and mechanistic evaluation of the large number of naturally occurring or synthesized compounds. This information led to the development of a new generation of derivative compounds. The development of radio protective agents has been the subject of intense research in view of their ...

INTRODUCTION Oral intake of vitamins which present antioxidant characteristics can protect living organisms against oxidative damage caused by exposure to ionizing radiation. It was previously reported that administration of high levels of vitamin C can lead to increased DNA damage through production of hydroxyl radicals from hydrogen peroxide by the Fenton reaction. However, our early experime...

and normal tissues. The nature and extent of such effects, however, depend on selected biological parameter (e.g., oxygen supply, cell cycle) and can be modified by chemical agents such as radiosensitizers, radioprotectors and chemotherapeutic agents. A precise control of the mode of action of the radiation is important in order to achieve the maximum effect on tumor tissue, while minimizing th...

Introduction: Oral intake of vitamins which present antioxidant characteristics can protect living organisms against oxidative damage caused by exposure to ionizing radiation. It was previously reported that administration of high levels of vitamin C can lead to increased DNA damage through production of hydroxyl radicals from hydrogen peroxide by the Fenton reaction. However, our early experim...

14.00 800x600 introduction: oral intake of vitamins which present antioxidant characteristics can protect living organisms against oxidative damage caused by exposure to ionizing radiation. it was previously reported that administration of high levels of vitamin c can lead to increased dna damage through production of hydroxyl radicals from hydrogen peroxide by the fenton reaction. however, our...

Introduction Approximately half of cancer patients will receive radiotherapy with either curative or palliative intent (1). Despite recent advances in radiotherapy treatment planning, normal tissue toxicity still limits the radiation dose that can be safely delivered (1). For example, when radiotherapy treatment is used to treat bladder or prostate cancer, it is often difficult to spare areas o...

Radiological terrorism and use of nuclear weapons are major concerns for national defense and homeland security. At low doses of radiation, the hazards from these scenarios may not be apparent immediately, but may result in late arising pathologies like cancer and pulmonary fibrosis. At high doses, the hazards vary from incapacitation due to nausea and diarrhea to mortality. Free radical specie...

•Dsup enhances radioresistance and tolerance to oxidative stress in D. melanogaster•Dsup can bind RNA•Dsup protein acts as an unspecific repressor of transcription•Dsup reduces the level locomotor activity melanogaster The tardigrade-unique damage suppressor (Dsup) protect DNA from ionizing radiation reactive oxygen species (ROS). In this study, we generated Dsup-expressing lines Drosophila dem...