Abstract DNA methylation profiling has emerged as a transformative prognostic tool in meningiomas, identifying distinct epigenetic subgroups that share unique clinical and biological features. Hypothesizing patterns may also reflect underlying pathogenic mechanisms, we investigated if this modality could be informative for the selection of efficacious chemotherapies focusing on FDA-approved com...

AT cells are extremely sensitive to ionizing radiation. Since the AT gene has homology to phosphatidylinositol 3 kinases(P13-kinases),wortman nm,a specificinhibitorofPI 3-kinase,wasusedtodetermineif P13-kinase activity regulates radiation sensitivity. Human and murine cells exposed to wortmannin alonedid not display significant cytotoxicity. Wortmanmn in combination with radiation was an effect...

The standard approaches of surgery or radiotherapy cure only a minority of patients with esophageal cancer. Because of these poor results and the frequent systemic pattern of recurrences, combined-modality therapy employing chemotherapy has been extensively studied. Preoperative chemotherapy, both alone and given concurrently with radiation, has not shown a significant impact on survival and re...