نتایج جستجو برای: radiosynthesis

تعداد نتایج: 363  

Journal: :Atom Indonesia 2022

The use of isopropanol as a hydroxyl radical scavenger on the radiosynthesis alginate-stabilized silver nanoparticles (AgNPs) can limit its application in nanomedicine. Meanwhile, optimum condition for gamma irradiation synthesis AgNPs without addition has not been reported yet. In this study, optimization process was carried out using response surface methodology (RSM) combined with Central Co...

Journal: :Journal of medicinal chemistry 2010
Li Liu Youwen Xu Colleen Shea Joanna S Fowler Jacob M Hooker Peter J Tonge

The front-line tuberculosis (TB) chemotherapeutics isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA) have been labeled with carbon-11 and the biodistribution of each labeled drug has been determined in baboons using positron emission tomography (PET). Each radiosynthesis and formulation has been accomplished in 1 h, using [(11)C]CH(3)I to label RIF and [(11)C]HCN to label INH and PZA. F...

Journal: :Organic & biomolecular chemistry 2018
Santosh R Alluri Patrick J Riss

A variety of substituted non-racemic aziridine-2-carboxylates equivalent to amino acids were prepared and subjected to ring opening reaction by [18F/19F]fluoride. The regio and stereospecific ring opening depends on the substituents on the nitrogen as well as both the carbons of aziridines. The applicability of the methods to afford access to 3-[18F/19F]fluoro amino acids are illustrated.

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