INTRODUCTION Approximately 10 - 20% of prostate cancer cases ultimately progress to castration-resistant prostate cancer (CRPC), for which there is a poor prognosis and a therapeutic need. Radium-223 dichloride (radium-223 [Xofigo]) is a first-in-class α-emitting radiopharmaceutical shown to significantly prolong overall survival in patients with CRPC with symptomatic bone metastases and no vis...

INTRODUCTION Bone seeking radiopharmaceuticals have been used for decades in the palliation of pain from bone metastases emerging from prostate cancer. Recent clinical evidence has demonstrated an improved survival in men with metastatic castration resistant prostate cancer (CRPC) with radium 223. MATERIAL AND METHODS A review of the literature was performed to identify the role of radiopharm...

This study aimed at evaluating natural radioactivity and radiation hazards of soils around a petroleum product marketing company due to anthropogenic influences using gamma ray spectrometry. Top (5 cm deep) were collected from diverse locations inside the premises Company standard analytical technique, while control samples acquired approximately 200 m area. Mean activity concentrations radionu...

The activity concentrations of naturally occurring radionuclides Ra-226, Th-232 and K-40, were measured by using a gamma ray spectrometry for coal, soil and water samples collected from the Barapukuria coal mine in Dinajpur district of Bangladesh. The average activity concentrations of Ra-226, Th-232 and K-40 in coal samples were found to be 6.21±3.68, 10.69±7.5 and 185.76±138.86 Bqkg, respecti...

We used two short-lived radium isotopes (223Ra, 224Ra) and a mass balance approach applied to the radium activities to determine the nutrient contribution of saline submarine groundwater discharge to the coastal waters of the northern Gulf of Aqaba (Israel). Radium isotope activities were measured along transects during two seasons at a site that lacked any obvious surficial water input. An ons...

Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer. Different radionuclides that emit β-rays such as (153)Samarium and (89)Strontium and achieve palliation are commercially available. In contrast to β-emitters, (223)Radium as a α-emitter has a short path-length. The advantage of the α-emitter is thus a highly loca...

Background: Radon is an odourless, colourless and tasteless gas and it is the first cause of lung cancer among non- smokers. The assessment of the level of radium in building materials helps in understanding the radiological implications. It has been observed that everyone has some levels of exposure to them. Therefore measurement of radium and radon in the soil samples are important f...

The activity concentrations of naturally occurring radionuclides Ra, Th and K in soil and water samples collected from Barapukuria 2×125 MW Coal Fired Thermal Power Plant area situated in Dinajpur district of Bangladesh were measured using gamma ray spectrometry technique. Two types of soil samples namely, active and passive soil samples and both surface and underground water samples were analy...

The activity concentration of Ra, Th and K was determined in solid and liquid samples collected from the TSP Fertilizer Factory, Chittagong, Bangladesh. A total of 18 samples of seven different kinds (including liquid and solid wastes) were collected and analyzed by gamma ray spectrometry technique using a high purity germanium (HPGe) detector of 40% relative efficiency. The analysis of the liq...