نتایج جستجو برای: randomized clinical study
تعداد نتایج: 4792268 فیلتر نتایج به سال:
Background and Aim: Randomized controlled clinical trial is the most valid type of epidemiological studies for the treatment of diseases. The aim of the present article is to determine the subject area, type of intervention, and blinding methods used in this type of study design. Materials and Methods: This is a cross-sectional descriptive study in which all the articles based on randomized c...
BACKGROUND It has previously been shown that testosterone implantation is an effective and well accepted form of androgen replacement therapy, but that pellet extrusion was the most frequent side-effect. The present study aimed to reduce the extrusion rate. OBJECTIVE To determine whether the washing of testosterone pellets to remove potentially surface-adherent particles decreased the rate of...
OBJECTIVE Hot flashes are a significant problem in women going through the menopausal transition that can substantially affect quality of life. The world of estrogen therapy has been thrown into turmoil with the recent results of the Women's Health Initiative trial report. Pursuant to a growing interest in the use of alternative therapies to alleviate menopausal symptoms and a few pilot trials ...
Background Apnea of prematurity (AOP) is a developmental disorder that affects the premature newborns frequently. One of the new non-drug methods for controlling apnea attacks is olfactory stimulation. The aim of this study was to determine the effect of olfactory stimulation by vanilla on the rate of apnea attacks in neonates with AOP. Materials and Methods: This study is a single-blind random...
OBJECTIVE To determine the efficacy of donepezil hydrochloride for the treatment of Alzheimer disease in patients drawn from clinical practice. DESIGN Two-center, randomized, placebo-controlled, double-masked crossover study. SETTING Memory disorders units at Massachusetts General and Brigham and Women's hospitals, Boston. PATIENTS Sixty individuals (30 men and 30 women; mean +/- SD age, ...
OBJECTIVES We evaluated the alleviation of post-tonsillectomy pain with systemic and topical applications. PATIENTS AND METHODS Data obtained from 78 patients (28 females, 50 males) who had undergone tonsillectomy for recurrent tonsillitis by conventional cold surgery were reviewed with prospective, randomized clinical study. Initially, the patients were assigned into topical and systemic dru...
BACKGROUND/AIMS Racial and ethnic minorities remain underrepresented in clinical research, yet few recruitment strategies have been rigorously evaluated. METHODS We experimentally tested whether targeted recruitment letters acknowledging diabetes health disparities and health risks specific to recipients' racial/ethnic group improved two metrics of trial participation: willingness to be scree...
Background & Aim: Randomized controlled trials often suffer from two major problems, i.e., noncompliance and missing outcomes. One potential solution to this problem is using the intention-to-treat (ITT) analysis approach. Therefore, the aim of this study was to review the concept of ITT and the most important issues related to it in practice since RCT researchers utilize it as a guide in order...
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