Abstract Background Colorectal cancer is one the most common cancers in western world with increasing incidence. Approximately 50% of patients develop liver metastases. Resection metastases treatment choice although almost half resected get recurrence liver. Methods The ASAC trial a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled study to determine whether adjuvant low...

A critical appraisal and clinical application of Weiss DJ, Casaburi R, Flannery R, LeRoux-Williams M, Tashkin DP. A placebo-controlled, randomized trial of mesenchymal stem cells in COPD. Chest. 2013;143(6):1590-1598. doi: 10.1378/chest.12-2094

Wagner KD, Berard R, Stein MB, et al. A multicenter, randomized, double-blind, placebo-controlled trial of paroxetine in children and adolescents with social anxiety disorder. Arch Gen Psychiatry 2004;61:1153–62. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

Title:Changes in fibroblast growth factor 23 levels in normophosphatemic patients with chronic kidney disease stage 3 treated with lanthanum carbonate: results of the PREFECT study, a phase 2a, double blind, randomized, placebo-controlled trial

BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease. Interleukin (IL) 13 type 2 cytokine that key to the inflammation underlying AD. Tralokinumab first-in-class, fully human, monoclonal antibody specifically binds with high affinity IL-13, neutralizing it in Immunomodulatory treatments may impair vaccine-induced immune responses.ObjectiveAssess responses standard vaccines ad...

We studied 26 patients in a randomized, placebo-controlled, double-blind parallel trial to evaluate the efficacy and safety of donepezil in chronic poststroke aphasia. Donepezil (10 mg/day) improved aphasia severity at endpoint (week 16) relative to placebo (p = 0.037).

To evaluate the efficacy of thiabendazole for prophylaxis of strongyloidiasis in patients with hematologic diseases, we performed a randomized, placebo-controlled trial. The incidence of strongyloidiasis was similar in both groups (p=0.36), but the compliance was better in the placebo group (p=0.04). This study does not support the use of thiabendazole prophylaxis in patients with hematologic d...

Scheffer RE, Kowatch RA, Carmody T, et al. Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in paediatric bipolar disorder after mood stabilization with divalproex sodium. Am J Psychiatry 2005;162:58–64. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

BACKGROUND It has been suggested in the literature that low-dose aspirin leads to an increased number of oocytes in IVF/ICSI as well as a higher pregnancy rate. The aim of the present study was to investigate the effect of daily administration of low-dose aspirin, compared with placebo, on pregnancy rate in IVF and ICSI. METHODS This study was a prospective, randomized, double-blind placebo c...

In this placebo-controlled phase II randomized clinical trial, we evaluated the safety and immunogenicity of a therapeutic prime-boost vaccine strategy using recombinant DNA (GTU-MultiHIV B clade) followed by boost vaccination with lipopeptide (HIV-LIPO-5) in HIV-infected patients on combined antiretroviral therapy. We show here that is well tolerated, consistently previous studies HIV-1-infect...