Background: The pit of Phoenix dactylifera contains different compounds such as saturated and unsaturated fatty acids, Zinc, Cadmium, Calcium and Potassium which could improve steroidogenesis. In this research, effect of phoenix dactylifera pit powder was evaluated on female rat reproduction. Materials and Methods: In this experimental study, 50 female wistar rats were divided in 5 groups of 10...

Background Maternal protein restriction during pregnancy promotes several alterations in the progeny. Previous studies showed that androgen/estrogen imbalances during perinatal period, can program prostate cells to develop prostate lesions in adult life after a second insult. This study aimed to investigate prostate diseases susceptibility in adult rat offspring which underwent in utero low pro...

Many gastrointestinal pain syndromes are more prevalent in women than men, suggesting a gonadal steroid influence. We characterized the effects of estrogen on two responses to colorectal distention (CRD) in the rat: the visceromotor reflex (vmr) and L6-S1 dorsal horn neuron activity (ABRUPT and SUSTAINED neurons). Ovariectomized rats were injected with estrogen, and responses to innocuous and n...

We used a model whereby mechanical stimulation induces bone formation in rat caudal vertebrae, to test the effect of estrogen on this osteogenic response. Unexpectedly, estrogen administered daily throughout the experiments (8-11 d) suppressed, and ovariectomy enhanced, mechanically induced osteogenesis. Osteogenesis was unaffected by the resorption-inhibitor pamidronate, suggesting that the su...

preterm contraction of uterus is a main cause of miscarriages and preterm labour. euphorbia known as ferphion in iranian traditional medicine texts like al-hawi, is reported for prevention of preterm labour. therefore, the objective of this research was to investigate the effect of euphorbia spinidens bornm. ex prokh. on motility of rat uterus. uterine horns were isolated form non-pregnant fema...

Background: Neurohormones like testosterone and estrogen play important roles in learning and memory. Estrogen receptors, densely expressed in the CA1 region of rat hippocampus, mediate the effects of estrogen on learning and memory. Estrogen receptors belong to a family of transcription factors, the nuclear receptor super family, and have two subtypes, estrogen receptor α and estrogen receptor...

BACKGROUND Gestational hypertensive disorders are a leading cause of maternal mortality in the US, accounting for up to 10% of these deaths. During pregnancy, a new rat model (SHHF rat) has been shown to develop spontaneous hypertension with increases of more than 40 mm Hg systolic blood pressure (BP), which resolves after delivery, and which lead us to ask whether the hypertension may be trigg...