Azelaic acid and its esters, the azelates, occur naturally in organisms ranging from plants to humans. We have shown that diethyl azelate (DEA) exhibits a broad range of immunomodulatory activities vitro vivo, mitigates insulin resistance. To further investigate therapeutic utility DEA, we evaluated mutagenicity Salmonella typhimurium strains, examined metabolism DEA rat, dog, monkey human prim...

Introduction: The role of different parts of the extended amygdala in metabolic signs of stress is not well understood. In the present study, we decided to evaluate the impact of the shell part of nucleus accumbens (NAc) on metabolic disturbance induced by electro foot shock stress using transient inactivation method in the rat.  Methods: Male Wistar rats (W: 230-250 g) were canuulated un...