Sphingosine 1-phosphate (S1P) influences heart rate, coronary artery caliber, endothelial integrity, and lymphocyte recirculation through five related high affinity G-protein-coupled receptors. Inhibition of lymphocyte recirculation by non-selective S1P receptor agonists produces clinical immunosuppression preventing transplant rejection but is associated with transient bradycardia. Understandi...

Landfill leachate recirculation is efficient in reducing the leachate quantity handled by a leachate treatment plant. However, after land application of leachate, nitrification and denitrification of the ammoniacal N becomes possible and the greenhouse gas nitrous oxide (N2O) is produced. Lack of information on the effects of leachate recirculation on N2O production led to a field study being c...

No longer simply a research tool, dynamic contrastenhanced MR imaging has become a clinically useful tool in brain imaging. T2 or T2* changes during the bolus passage of a paramagnetic contrast agent through the cerebrovascular system are converted to concentration values, and indicator dilution theory is applied to calculate a number of hemodynamic variables. Since Rosen et al first reported d...

Vortex breakdown is a phenomenon inherent to many practical problems, such as leading-edge vortices on aircraft, atmospheric tornadoes, and flame-holders in combustion devices. The breakdown of these vortices is associated with the stagnation of the axial velocity on the vortex axis and the development of a near-axis recirculation zone. For large enough Reynolds number, the breakdown can be tim...

Recovery of protein synthesis following 1 h of complete ischemia of the monkey brain was assessed by 3H-labeled amino acid incorporation in vivo at various postischemic periods between 1.5 and 24 h. The regional autoradiographic patterns obtained were compared on the basis of precursor-product relationships determined biochemically at the end of the tracer incorporation studies. Shortly after i...

Previous studies showed that in rats exposed to 30 min of forebrain ischemia, there were reductions in pyruvate-supported respiration within the first 3 h of recirculation in mitochondria isolated from the dorsolateral striatum (a region in which the majority of neurons are susceptible to ischemia) but not the ischemia-resistant paramedian neocortex. The present study demonstrates that the chan...

We present results from Spitzer Space Telescope observations of the mid-infrared phase variations of three short-period extrasolar planetary systems: HD 209458, HD 179949 and 51 Peg.We gathered Infrared Array Camera (IRAC) images in multiple wavebands (3.6 μm or 4.5 μm, and 8 μm) at eight phases of each planet’s orbit. We find the uncertainty in relative photometry from one epoch to the next to...

The laser-light-sheet-assisted smoke flow visualization technique is performed on a full-size, transparent, commercial grade chemical fume cupboard to diagnose the flow characteristics and to verify the validity of several current containment test methods. The visualized flow patterns identify the recirculation areas that would inevitably exist in the conventional fume cupboards because of the ...

The overuse of its currency processing facilities by depository institutions (DIs) has motivated the Federal Reserve (Fed) to impose its new cash recirculation policy. This overuse is characterized by the practice of cross-shipping, where a DI both deposits and withdraws cash of the same denomination in the same business week in the same geographical area. Under the new policy, which came into ...

Five current meter moorings and four horizontal electric field records spanning June 1990–February 1992 are used to describe the mean structure and variability of the vertically averaged velocity field and volume transport extending 425 km east of Abaco, The Bahamas, at 26.58N. Examination of zonal and meridional velocity sections shows that, while meandering may explain part of the variability...