This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. Dear Editor The lattice corneal dystrophies (LCD) are characterized by an accumu...

BACKGROUND Trichiasis surgery is believed to reduce the risk of losing vision from trachoma. There are limited data on the long term outcome of surgery and its effect on vision and corneal opacification. Similarly, the determinants of failure are not well understood. METHODS A cohort of people in the Gambia who had undergone surgery for trachomatous trichiasis 3-4 years earlier was re-assesse...

Inherited skin fragility disorders comprise a group of disorders, mainly designated as epidermolysis bullosa (EB), that are characterised by mechanical induced blistering and erosions of the skin and mucous membranes caused by mutations of gene coding for protein components of the dermal–epidermal junction zone. Patients with EB experience various degrees of recurrent skin blistering, widesprea...

Erosions of articular cartilage are often seen in the knee joint in association with certain internal derangements such as meniscus tears or after recurrent subluxation of the patella (Helfet 1959, Smillie 1962). Also a number of studies have appeared on the pathology of articular cartilage after injury, both in man (Landells 1957) and in experimental animals (Barnett 1956. Tallqvist 1962, Meac...

M e t h o d s Data sources: 5 databases, bibliographies of relevant studies, and contacting authors. Study selection and assessment: Randomized controlled trials (RCTs) ≥ 21 days in duration comparing 1 of the 5 gastroprotective strategies with nonselective NSAIDs alone on outcomes of GI toxicity. Quality assessment included randomization procedures, allocation concealment, blinding, and follow...

The protective efficacy of a glycoprotein D subunit vaccine (gD2 SB AS4) was evaluated in a mouse model of human recurrent herpetic stromal keratitis (HSK). When administered before primary infection, gD2 SB AS4 protected mice against corneal pathology, mortality, and latency resulting from ocular viral challenge with herpes simplex virus type 1 (HSV-1) McKrae strain. In addition, gD2 SB AS4 si...

Virion host shutoff (vhs)-deficient herpes simplex virus (HSV) was tested as a therapeutic vaccine in a mouse model of UV light-induced recurrent herpetic stromal keratitis. Four weeks after primary corneal infection, mice were vaccinated intraperitoneally with vhs(-) vaccine or control. Four weeks after vaccination, the eyes of latently infected mice were UV-B irradiated to induce recurrent vi...

PURPOSE We designed the current study to determine the protective effects of lornoxicam, a cyclooxygenase (COX) inhibitor, on recurrent herpetic stromal keratitis (HSK) and the nuclear factor-kappaB (NF-kappaB)-mediated mechanism in mice. METHODS A corneal latent herpes simplex virus-1 (HSV-1) infected mouse model was established. Six weeks later, Ultraviolet B (UVB) irradiation induced the r...