Recurrent pregnancy loss is a common problem in the reproductive age population of women. It can be caused by many different conditions. This addressed international guidelines that take slightly approach to its diagnosis and treatment. The used this review mainly use Royal College Obstetricians Gynaecologists (RCOG), American Society Reproductive Medicine (ASRM) European Human Reproduction Emb...

Recurrent pregnancy loss may be a consequence of an abnormal embryonic karyotype, or maternal factors affecting the endometrium resulting in defective implantation. In order to study the endometrial factors responsible for recurrent pregnancy loss, endometrial biopsy samples should be precisely timed according to the LH surge, and the investigation should be carried out in a non-conception cycl...

Genetic factors in the form of maternal or fetal single gene disorders, chromosomal abnormalities, inherited thrombophilia and other genes involved are the main causes of recurrent abortion (RA). The risk of miscarriage is highest among couples where the woman is >35 years of age and the man >40 years of age. In about 50–70% of miscarriage, a chromosome abnormality is identified in the products...