Nanotechnology has been extensively explored for drug delivery. Here, we introduce the concept of a nanodrug based on synergy of photothermally-activated physical and biological effects in nanoparticle-drug conjugates. To prove this concept, we utilized tumor necrosis factor-alpha coated gold nanospheres (Au-TNF) heated by laser pulses. To enhance photothermal efficiency in near-infrared window...

Measurements of partially spatially coherent infra-red laser beam intensity fluctuations propagating through a hot-air turbulence emulator are compared with visible laser beam intensity fluctuations in the maritime and IR laser beam intensity fluctuations in the terrestrial environment at the United States Naval Academy. The emulator used in the laboratory for the comparison is capable of gener...

High-order harmonic generation (HHG) is a nonlinear nonperturbative process in ultrashort intense laser-matter interaction. It is the main source of coherent attosecond (1 as = 10 s) laser pulses to investigate ultrafast electron dynamics. HHG has become an important table-top source covering a spectral range from infrared to extreme ultraviolet (XUV). One way to extend the cutoff energy of HHG...

The ability to inject exogenous material as well as to alter subcellular structures in a minimally invasive manner using a laser microbeam has been useful for cell biologists to study the structure-function relationship in complex biological systems. We describe a quantitative phase laser microsurgery system, which takes advantage of the combination of laser microirradiation and short-coherence...

Here we report two novel red emission fluorescent probes for the highly sensitive and selective detection of monoamine oxidase (MAO) with large Stokes shift (227 nm). Both of the probes possess solid state fluorescence and can accomplish the identification of MAO on test papers. The probe MAO-Red-1 exhibited a detection limit down to 1.2 μg mL(-1) towards MAO-B. Moreover, the cleavage product w...

This work describes a new approach to the delivery of light in deeper tissues, through a silk filament that is implantable, biocompatible, and biodegradable. In the present work, silkworm gut fibers (SGFs) of Bombyx mori L., are made by stretching the silk glands. Morphological, structural, and optical properties of the fibers have been characterized and the stimulatory effect of red laser ligh...

Imaging the four fluorescence bands of leaves, red (F690) and far-red (F740) chlorophyll (Chl) as well blue (F440) green (F520) leaves corresponding ratios is a fast excellent nondestructive technique to detect photosynthetic activity capacity gradients over leaf area effect various strain stress parameters on plants. This review primarily deals with first pioneering multi-colour imaging result...