Amiodarone is an investigational antiarrhythmic agent known to cause pulmonary toxicity. This report describes two patients with previous amiodarone pulmonary toxicity and complete resolution who at rechallenge 5 to 6 months later developed within 2 weeks of therapy a significant reduction in lung diffusion capacity before overt clinical toxicity occurred. This suggests that toxicity may presen...

IN A PREVIOUS STUDY of the pulmonary capillary bed in mitral valve disease,' the mean value for pulmonary diffusing capacity for carbon monoxide (DL) was found to be significantly lower than normal, in agreement with several other reports.2 7 This was due mainly to impairment of the membrane diffusing capacity (DM). Reduction in pulmonary capillary blood volume (V,) was found only in patients w...

Graphene oxide (GO) is a highly effective adsorbent, and its absorbing capability is further enhanced through its in situ reduction with sodium hydrosulfite as the reductant. Acridine orange is the selected target to eliminate with GO as the adsorbent. Under identical conditions, GO without the in situ reduction showed a maximum adsorption capacity of 1.4 g g(-1), and GO with the in situ reduct...

Information and communication technology (ICT) tools are known to facilitate communication and processing of information and sharing of knowledge by electronic means. In Nigeria, the lack of adequate capacity on the use of ICT by health sector policymakers constitutes a major impediment to the uptake of research evidence into the policymaking process. The objective of this study was to improve ...

Oxidative stress has been proposed to be a unifying cause for diabetic nephropathy and a target for novel therapies. Here we apply a new endogenous reduction-oxidation (redox) sensor, hyperpolarized (HP) (13)C dehydroascorbate (DHA), in conjunction with MRI to noninvasively interrogate the renal redox capacity in a mouse diabetes model. The diabetic mice demonstrate an early decrease in renal r...