how to cite this article: mollamohammadi m, tonekaboni sh, pirzadeh z, vahedian m . pregabalin in childhood epilepsy: a clinical trialiran j child neurol. 2014 autumn;8(4): 62-65. abstract objective the prevalence of active epilepsy is about 0.5–1%, and approximately 70% of patients are cured with first anti-epileptic drugs and the remaining patients need multiple drugs. pregabalin as an add-on...

Objectives: We assessed the comparative efficacy and tolerability of topiramate (TPM), lamotrigine (LTG), gabapentin (GBP) and clobazam (CLB) with an aim to formulate clinical guidelines while initiating treatment with new anti-epileptic drugs (AEDs). Methods: A prospective open label, nonrandomized, add-on study was conducted on 203 Indian patients with seizures refractory to conventional AEDs...

Vagus nerve stimulation versus ''best drug therapy'' in epilepsy patients who have failed best drug therapy I would like to thank Dr. Hoppe and colleagues for their recent study published in Seizure examining vagus nerve stimulation (VNS) versus ''best drug therapy'' in medically refractory epilepsy patients. 1 However, I have concerns regarding the authors' methodology and conclusions. In this...

Abstract Current guidelines advocate to treat refractory status epilepticus (RSE) with continuously administered anesthetics induce an artificial coma if first- and second-line antiseizure drugs have failed stop seizure activity. A common surrogate for monitoring the depth of is appearance a burst-suppression pattern (BS) in EEG. This review summarizes current knowledge on origin neurophysiolog...

Garcinia cambogia (G.cambogia) is a herbal dietary supplement for managing obesity. Several adverse effects of G.cambogia have been reported including serotonin syndrome and mania. We report patient with refractory status epilepticus after taking G.cambogia. A 24-year-old woman was admitted continuing seizures. Based on electroencephalography neuroimaging findings, she diagnosed as attributed t...

BACKGROUND Epilepsy is a common neurologic complication of tuberous sclerosis complex (TSC) and it is often refractory to treatment. Therefore, treating physicians are often reluctant to discontinue antiepileptic drugs (AEDs) in individuals with TSC who have attained seizure remission. To our knowledge, seizure remission and AED discontinuation in children with TSC has not been studied. OBJEC...

the differentiation of vasovagal syncope and epileptic seizure is sometimes problematic, since vasovagal syncope may mimic epileptic seizures in many ways. the present report describes a patient who had been diagnosed and treated as having epilepsy with medically-refractory sei-zures for 16 years. often, unlike epileptic seizures, tonic-clonic convulsions and postictal confusion are uncommon fe...