PURPOSE Cortico-amygdalohippocampectomy (CAH) has become an important treatment option for patients with refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS); it has resulted in a 60-70% seizure remission rate and significant quality of life (QOL) improvements. Video-electroencephalography (VEEG) monitoring has been widely used in epilepsy centers for pre-surgical evaluatio...

OBJECTIVE Epilepsy is the most common neurological chronic condition worldwide, affecting about 2% of world population. Temporal lobe epilepsy (TLE) reaches 40% of all cases of this condition, and it is highly refractory to pharmacological treatment. Physical activity has been suggested as complementary therapy for epilepsy. However, there is no consistent information whether all these effects ...

Patients with limbic encephalitis usually present with new onset mesial temporal lobe seizures, progressive memory disturbance, and a variety of other behavioral, emotional, and cognitive changes. Autoimmune inflammation of the limbic gray matter structures of the human brain has recently been identified as major cause of mesial temporal lobe epilepsy with interictal temporal epileptiform activ...

Objective—Intractable epilepsy is related to various transient and chronic brain electric and neurochemical disturbances. There is increasing evidence that chronic epilepsy induces secondary neuronal metabolic and structural decline. However, there is no convincing evidence that the cognitive abilities of patients deteriorate with increasing duration of intractable epilepsy. Methods—To examine ...

Frontal lobe epilepsy makes up between 20 and 30% of all partial epilepsies and is the biggest subgroup of the extratemporal lobe epilepsies. Of the patients who undergo surgery for epilepsy up to 18% have a frontal lobe focus. The aetiology of frontal lobe epilepsy is varied, clinical semiology is diverse and seizures are often frequent, disabling and refractory to treatment. Imaging and EEG f...

BACKGROUND Fludeoxyglucose F 18 positron emission tomography ((18)F-FDG-PET) can detect focal metabolic abnormalities ipsilateral to the seizure focus in 80% of patients with temporal lobe epilepsy (TLE). Regions outside the epileptogenic zone can also be affected. We hypothesized that these remote regions might show altered metabolism, tending to return toward normal values, after surgery. D...

Mesial temporal lobe epilepsy (MTLE) is one of the most common types focal in adult population. MTLE frequently associated with a specific histopathological lesion medial structures, namely hippocampal sclerosis (HS). A significant proportion patients MTLE+HS have severe epilepsy, which often resistant to clinical treatment. For these patients, surgical resection epileptogenic can be performed....

PET and SPECT are valuable clinical tools in the management of patients with medically resistant, partial epilepsy who are under evaluation for surgical treatment. The value of PET for localization of seizure activity has been fi rmly established for patients with temporal lobe epilepsy and extratemporal lobe epilepsy. It is a very useful test partly because it is non-invasive. The localizing v...