Introduction: Metabolic reprogramming is a hallmark of cancer progression. However, there are few studies in mantle cell lymphoma (MCL). Protein arginine methyltransferase 5 (PRMT5), catalyzes monomethylation and symmetric demethylation residues on histone nonhistone proteins participates tumor This study aimed to investigate the mechanism PRMT5-induced lipid MCL. Method: Lymph node, bone marro...

The regulation of cellular dimension is important for the function and survival of cells. Cellular dimensions, such as size and shape, are regulated throughout the life cycle of bacteria and can be adapted in response to environmental changes to fine-tune cellular fitness. Cell size and shape are generally coordinated with cell growth and division. Cytoskeletal regulation of cell shape and cell...

Abstract Cancer development is a complicated process controlled by the interplay of multiple signaling pathways and restrained oxygen nutrient accessibility in tumor microenvironment. High plasticity using diverse nutrients to adapt metabolic stress one hallmarks cancer cells. To respond meet requirements for rapid cell proliferation, cells reprogram take up more glucose coordinate production e...

Objective(s): Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lines is the objective of this research. Material and Methods:Metabolism of c...

Non-coding microRNAs are involved in multiple regulatory mechanisms underlying response of cancer cells to stress leading to apoptosis, cell cycle arrest and autophagy. Many molecular layers are implicated in such cellular response including epigenetic regulation of transcription, RNA processing, metabolism, signaling. The molecular interrelationship between tumor protein (TP)-p53 family member...

with advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. chromatin insulators are key determinants of proper gene regulation and precise organization of c...

Abstract Hepatocellular carcinoma (HCC) is a heterogeneous disease that often features dysregulated tumour lipid metabolism. ACSL3 and ACSL4 are two homologous long chain acyl‐coenzyme A synthetases (ACSL) preferentially catalyse the activation of monounsaturated polyunsaturated fatty acids, respectively. Both enzymes frequently overexpressed in HCC, multiple reports have implicated progression...

G protein coupled receptor kinase 2 (GRK2) has a key role in cellular function by regulating different intracellular mechanisms in a kinase dependent or independent manner. In this review we have dealt with the recently discovered roles of GRK2 in the regulation of cell metabolism. In particular, we have focused on recent findings about the mitochondrial role of GRK2 in the regulation of energy...