regulatory systems

Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF-DNA interactions, generating and interrogating an array of 423 full-length Dro...

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altered suppressor function of regulatory t cells in type 1 diabetes

Journal: :iranian journal of immunology 0

babak aghili department of immunology, school of medicine ali akbar amirzargar department of immunology, school of medicine asadollah rajab department of endocrinology, iranian diabetes association ali rabbani growth and development center, tehran university of medical sciences, children&#039;s medical center arya sotoudeh growth and development center, tehran university of medical sciences, children&#039;s medical center sara assadiasl department of immunology, school of medicine bagher larijani

background: type 1 diabetes (t1d) is a t cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. autoimmune diseases may develop as a consequence of altered balance between regulatory (tregs) and autoreactive t cells. objectives: to evaluate treg cells frequency and suppressive function in the peripheral blood of newly diagnosed t1d patients in compari...

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