Arecent phase III study suggests that a novel autologous tumour-based vaccine could reduce disease recurrences in patients who have had surgery for renal-cell carcinoma (RCC). The results, published in the Lancet (2004; 363:594–559) show that the new tumour vaccine lowers the relative risk of metastases and/or relapse in RCC patients by approximately 30% and thereby may prolong their life expec...

PURPOSE The differentiation of oncocytoma from renal cell carcinoma (RCC) remains a challenge with currently available cross-sectional imaging techniques. As a result, a large number of patients harboring a benign oncocytoma undergo unnecessary surgical resection. In this study, we explored the utility of 99mTc-MIBI SPECT/CT for the differentiation of these tumors based on the hypothesis that t...

The introduction of targeted therapies has caused a paradigm shift in the treatment of metastatic clear cell (cc)-renal cell carcinoma (RCC). We hypothesized that determining differential kinase activity between primary and metastatic tumor sites may identify critical drivers of progression and relevant therapeutic targets in metastatic disease. Kinomic profiling was performed on primary tumor ...

*Correspondence: Marcin Tabaka, Tomasz Kalwarczyk and Robert Holyst, Department of Soft Condensed Matter and Fluids, Institute of Physical Chemistry of the Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland e-mail: [email protected]; [email protected]; [email protected] We discuss a quantitative influence of macromolecular crowding on biological processes: motion, bimo...

Integrating photonics with CMOS electronics in silicon is essential to enable chip-scale, electronic-photonic systems that will revolutionize classical and quantum communication computing systems. However, the lack of an on-silicon isolator, capable blocking unwanted back reflections ensuring stable operation laser, precluded many previous demonstrations from providing single-chip solutions. Fo...

this paper develops an analysis of budget deficit financing in termsof a crowding out or crowding in effect on the activity of the privatesector for the economies of iran and algeria as two mena countries,(because of its economic structures (dependence on oil revenue)) duringthe period 1970-2012 by using cointegration and vector errorcorrection approaches. the analysis confirms the existence of...

conclusions there were no significant differences in the survival rates and short-term postoperative complications between the laparoscopic partial nephrectomy group and the laparoscopic radical nephrectomy group for small rcc, but the former was slightly more effective. background renal cell carcinoma (rcc) is a common malignancy of the urinary system with high rates of morbidity and mortality...

PURPOSE Metastatic renal cell carcinoma (RCC) has a poor prognosis and an unpredictable course. To date, there are no molecular markers which can reliably predict RCC outcome. We investigated whether a novel kidney cancer marker, carbonic anhydrase IX (CAIX), is associated with progression and survival. EXPERIMENTAL DESIGN Immunohistochemical analysis using a CAIX monoclonal antibody was perf...

Using various spectroscopic techniques such as UV-visible spectroscopy, circular dichroism spectroscopy, NMR spectroscopy, small-angle X-ray scattering, transient grating, and transient absorption techniques, we investigated how cell-mimetic environments made by crowding influence the photocycle of photoactive yellow protein (PYP) in terms of the molecular volume change and kinetics. Upon addit...