The aim of the current study was to formulate Fexofenadine hydrochloride loaded sustained release microspheres using HPMC K100 M CR, a release retardant hydrophilic polymer by solvent evaporation method. The effect of different drug loading on drug content, drug encapsulation efficiency and release of drug was monitored. The studies on in vitro release mechanism were performed using USP paddle ...

6 Summary Summary Two kinetically distinct components of transmitter release have been observed in Ca 2+ uncaging experiments at a CNS synapse in rats, and both release components showed a steep dependence of release kinetics on [Ca 2+ ] i. These findings were based on simultaneous pre-and postsynaptic whole-cell voltage-clamp recordings from the calyx of Held synapse, combined with presynaptic...

We study a model of multi-legged catalytic molecular walkers that abstract a class of recently developed synthetic molecular motors. We focus on their kinetics of release of catalytic product, delineating the influence of chemical kinetic parameters, geometric configuration, loss from surface, and bulk kinetics. We show that such walkers can achieve a uniform rate of release over long time scal...

Objective (s): Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.Materials and Methods:Everydiscs containing 70 mg stem bark extract of Ziziphus jujuba were formulated  by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation  and direct compression. Discs were standardized based on the total phenol.  Properties such as in vi...

The aim of the present work was to prepare and characterize biopolymer nanocarriers and evaluate their suitability in possible oral delivery of insulin. The egg albumin biopolymer was used to prepare nanoparticles which were further characterized by Fourier transformed Infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), zeta potential, Dynam...

The aim of the present work was to prepare and characterize biopolymer nanocarriers and evaluate their suitability in possible oral delivery of insulin. The egg albumin biopolymer was used to prepare nanoparticles which were further characterized by Fourier transformed Infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), zeta potential, Dynam...

This paper presents localized and temporal control of release kinetics over 3-dimensional (3D) hybrid wound devices to improve wound-healing process. Imaging study is performed to extract wound bed geometry in 3D. Non-Uniform Rational B-Splines (NURBS) based surface lofting is applied to generate functionally graded regions. Diffusion-based release kinetics model is developed to predict time-ba...

The study presents the evaluation of the controlled release kinetics for an active pharmaceutical substance BPMDMDHI–(2-[(1-benzyl-4-piperidyl) methyl]-5, 6-dimethoxy-2, 3-dihydroinden-1-one), physically incorporated in the PVA polymeric matrix and used under a patch form. The substance presents more polymorphic forms. Our study was made for two different polymorphs of BPMDMDHI (donepezil): A a...

Inhibition kinetics of single-beta-galactosidase molecules with the slow-binding inhibitor d-galactal have been characterized by segregating individual enzyme molecules in an array of 50,000 ultra small reaction containers and observing substrate turnover changes with fluorescence microscopy. Inhibited and active states of beta-galactosidase could be clearly distinguished, and the large array s...

The incorporation of different cyclodextrin (CD) excipients such as HPbeta-CD, beta-CD, gamma-CD or alpha-CD into polymer millirods for complexing beta-lapachone (beta-lap), a potent anti-cancer drug, significantly improved the drug release kinetics with various drug release patterns. However, such a complex system requires a mechanistically based model in order to provide a quantitative unders...