blood pressure rises rapidly upon awakening and maybe responsible, in part, for the increased incidence of myocardial infarction and stroke during the morning hours. the aim of the present study was, therefore, to develop a novel chronotherapeutic formulation of metoprolol tartrate (mt) for night time dosing providing maximum effect in the morning hours. core tablets contained mt, sodium chlori...

A carrier system based on nanoporous silica (SBA-15) with magnetic nanoparticles of CoFe2O4 was synthesized via the impregnation of cobalt salt, iron salt and citric acid with as-synthesized SBA-15. The obtained samples were characterized by small angle X-ray scattering (SAXS), N2 adsorption/desorption, scanning electron microscopy (SEM), vibrating sample magnetometer (VSM) and ultraviolet (UV)...

This work aims at studying the loading rate dependency of mode I delamination growth in CFRPs, using typical fracture toughness analysis through both R-curve and crack tip opening rate. The average SERR is a method data reduction based on energy balance which has been previously introduced to characterize under different types conditions similar manner. In present research, application this was...

Nano-structured surface and its ability to dual release of osteogenic and anti-inflammatory agents have a positive effect on the success of using titanium in orthopedic applications. For this purpose, TiO2 nanotubes (TNTs) were created via anodization method on Ti sheets and loaded by β-glycerophosphate (GP) and dexamethasone (DEX) as osteogenic and anti-inflammatory agents, respecti...

Zeolite application to clayey soils may change potassium (K) pools distribution and its release rate. To test this hypothesis, two heavy-textured calcareous soils with different mineralogy (smectitic and mixed by XRD) from southern Iran were selected. Experiment was a completely randomized factorial arrangement. Treatments consisted of two soils and two zeolite levels (0 and 5%) and wetting-dry...

a carrier system based on nanoporous silica (sba-15) with magnetic nanoparticles of cofe2o4 was synthesized via the impregnation of cobalt salt, iron salt and citric acid with as-synthesized sba-15. the obtained samples were characterized by small angle x-ray scattering (saxs), n2 adsorption/desorption, scanning electron microscopy (sem), vibrating sample magnetometer (vsm) and ultraviolet (uv)...

Sodium salicylate containing microemulsions have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant and oil. The effects of formulation variables on the release profile of the drug from microemulsion through intact rat skin were also determined experimentally. In this investigation, two commercially available lecithins (namely Epikuron 2...

Delamination fracture of a two-dimensional functionally graded multilayered four-point bending beam that exhibits non-linear behaviour of the material is analyzed. The fracture is studied analytically in terms of the strain energy release rate. The beam under consideration has an arbitrary number of layers. Each layer has individual thickness and material properties. A delamination crack is loc...