Microvascular responses in the cremaster muscle were compared with changes in mean arterial pressure and hindquarters vascular resistance during the development (initial 3 hours) of two-kidney one-clip renal hypertension in rats, to examine the possibility that an autoregulatory mechanism may contribute to the development of hypertension. Rats were anesthetized with urethane and chloralose and ...

PURPOSE The natural history of renal artery stenosis is progression with subsequent deterioration of kidney function and development of renovascular hypertension. Percutaneous transluminal renal angioplasty is effective in the treatment of nonostial lesions but less effective for ostial stenoses. Because of the poor technical success experienced with percutaneous transluminal renal angioplasty,...

BACKGROUND Single-electrode ablation of the main renal artery for renal sympathetic denervation showed mixed blood pressure (BP)-lowering effects. Further improvement of the technique seems crucial to optimize effectiveness of the procedure. Because sympathetic nerve fibers are closer to the lumen in the distal part of the renal artery, treatment of the distal main artery and its branches has b...

OBJECTIVES The aim of this prospective randomized study was to assess the impact of renal artery denervation in patients with a history of refractory atrial fibrillation (AF) and drug-resistant hypertension who were referred for pulmonary vein isolation (PVI). BACKGROUND Hypertension is the most common cardiovascular condition responsible for the development and maintenance of AF. Treating dr...

Abstract We report a case of 4-year-old boy who presented with moyamoya disease associated midaortic syndrome. He had been treated for severe persistent hypertension until he suffered multiple episodes seizure and cerebral ischemic attack. Cerebral angiography showed bilateral terminal internal carotid artery stenosis. Angiographic survey stenosis abdominal aorta proximal renal arteries. This i...

To gain information concerning cardiorenal hemodynamics in essential hypertension, renal vascular disease, and chronic glomerulonephritis, indocyanine green was used to determine renal blood flow (RBF), renal blood volume (RBV), mean transit time (MTT), appearance time (AT), buildup time (BT), and passage time (PT), in 83 kidneys of 47 hypertensive patients and eight volunteers. Cardiac output ...

Fibromuscular dysplasia (FMD) is a noninflammatory disease affecting small- and medium-sized arteries of the renal and the carotids. It affects the renal arteries in nearly 60%-75% cases. The primary clinical manifestation of renal FMD is hypertension. Medial fibroplasia represents the most common dysplastic lesion. We report two cases who presented with hypertension and renal insufficiency and...

We examined the relationship of hypertension and plasma renin activity to atherogenesis in 48 moderately hyperlipidemic (total serum cholesterol was about 200 mg/dl) baboons (Papio sp.). We used renal artery stenosis (two-kidney, one clip model) to produce hypertension associated with elevated plasma renin activity, and used cellophane wrapping of both kidneys (bilateral perinephritis model) to...

INTEREST in unilateral renal disease as a possible cause of human hypertension originated with Goldblatt 's classic experiments.' In 1937, Butlerreported the clinieal cure of hypertension following nephrectomy in two cases of unilateral, pyelonephritis with vascular disease in children. In recent years it has been recognized that many cases of human hypertension are on the basis of unilateral r...