Coronary and renal blood flows are important for maintaining cardiac and renal function. Endothelial cells (ECs) play critical roles in forming new vessels and regulating vessel functions. ECs also protect the surrounding tissues by secreting a variety of biologically active substances. Endothelial dysfunction occurs in various forms of cardiovascular and renal diseases. It plays a fundamental ...

Introduction. The aim of this study was to assess the interaction of liver and renal dysfunction as risk factors for mortality after liver resection. Materials and Methods. A retrospective analysis of 501 patients undergoing liver resection in a single unit was undertaken. Posthepatectomy liver failure (PHLF) was defined according to the International Study Group of Liver Surgery (ISGLS) defini...

BACKGROUND In resource-limited settings, routine monitoring of renal function during antiretroviral therapy (ART) has not been recommended. However, concerns for tenofovir disoproxil fumarate (TDF)-related nephrotoxicity persist with increased use. METHODS We investigated serum creatinine (S-Cr) monitoring rates before and during ART and the incidence and prevalence of renal dysfunction after...

Although preclinical and clinical studies have demonstrated that relaxin (RLX) ameliorates impaired renal function by exerting antifibrotic and regenerative effects, its role in renal ischemia/reperfusion (I/R) injury has never been investigated. Using a well-known rat model of 1 h bilateral renal artery occlusion followed by 6 h reperfusion, we investigated the effects of human recombinant RLX...

Microvascular disease has been linked with renal dysfunction in patients with diabetes. The aim of this study was to examine the association of retinal microvascular abnormalities to renal dysfunction among participants of the Atherosclerosis Risk in Communities Study, a population-based investigation in four U.S. communities. At the third examination (1993 to 1995), retinal photography was per...

COMMON CAUSES of renal allograft dysfunction include acute rejection, cyclosporine or FK506 toxicity, acute tubular necrosis, and chronic allograft nephropathy. Important but less frequent causes are recurrent and de novo diseases in the allograft. We report the case of a 66-year-old man who developed renal insufficiency 8 months posttransplantation. A novel cause of renal allograft dysfunction...

Co-incidence of atrial fibrillation and renal dysfunction in general population is described in many epidemiological studies. Major issue is optimal anticoagulation in patients with atrial fibrillation and renal disease warranting balance between risks of ischemic stroke and hemorrhages. The second issue is catheter ablation of AF patients with renal dysfunction. Both issues are discussed in th...

This study was designed to elucidate the role of peroxisome proliferator-activated receptor (PPAR)-alpha in the development of inflammation after ischemia/reperfusion injury of the kidney. We have evaluated the effects of ischemia/reperfusion on renal dysfunction, injury, and inflammation in wild-type mice or mice in which the gene for PPAR-alpha has been deleted [PPAR-alpha(-/-)] and then trea...

The longer survival of liver transplant recipients has emphasized the need to consider complications that develop several years after liver transplantation, such as chronic renal dysfunction. Renal dysfunction has an impact on long-term posttransplant morbidity and mortality. The prevalence of chronic renal disease among liver transplant recipients varies widely from 10 to 78%. This renal dysfu...