BACKGROUNDS Despite the potential therapeutic benefits, cell therapy in renal ischemia-reperfusion (I/R) injury is currently limited by low rates of cell engraftment after systemic delivery. In this study, we investigate whether locally administration through renal artery can enhance the migration and therapeutic potential of mesenchymal stem cells (MSCs) in ischemic kidney. METHODS The model...

Classical effects of mineralocorticoids include stimulation of Na(+) reabsorption and K(+) secretion in the kidney and other epithelia including colon and several glands. Moreover, mineralocorticoids enhance the excretion of Mg(2+) and renal tubular H(+) secretion. The renal salt retention following mineralocorticoid excess leads to extracellular volume expansion and hypertension. The increase ...

tention in a series of 12 patients, according to Sodee, and he discontinued the mercuhydrin injection ( 7 ). McAfee noted that pharmacologists have been unable to block the uptake in the kidneys, despite pre-dosing rats with cold mercurials with doses up to 20 mg of mercury per kilogram, a tremendously toxic dose (8). Although brain scanning with such short-lived isotopes as 99mTcand 197Hg is r...

1. In previous studies we found that albumin infusions caused only a modest natriuresis in the nephrotic syndrome, suggesting that hypovolaemia played no part in the sodium retention of these patients. However, this finding was inconclusive, since the hyperoncocity of the infused albumin probably opposed sodium excretion. 2. In the present study, we examined the effect of sustained (68 h) plasm...

BACKGROUND Neutral endopeptidase 24.11 (NEP) is a metalloprotease that is localized in the greatest abundance in the kidney and degrades natriuretic peptides, such as atrial natriuretic peptide (ANP). Mild congestive heart failure (CHF) is characterized by increases in circulating ANP without activation of the renin-angiotensin-aldosterone system (RAAS) or sodium retention. In contrast, severe ...

In 2006, a connection was made between Gadolinium-based Contrast Agents (GBCAs) administered for contrast-enhanced MRIs and Nephrogenic Systemic Fibrosis (NSF). NSF is a potentially fatal disease that has been diagnosed almost exclusively in patients with end-stage renal disease (ESRD). Prolonged excretion times and the instability of the GBCA results in the toxic gadolinium ion separating from...

Aldosterone plays a pivotal role in NaCl and K(+) homeostasis by stimulation of Na(+) reabsorption and K(+) secretion in the aldosterone-sensitive distal nephron (ASDN). Recent studies demonstrated that the serum- and glucocorticoid-regulated kinase 1 (Sgk1) is induced by aldosterone in the ASDN and that polymorphisms of the kinase associate with arterial blood pressure in normotensive subjects...

D RUGS to promote the excretion of water in edematous states of varied etiology form an essential part of the equipment of every practitioner. Although the common denominator of all types of edema appears to be sodium retention by the kidney, many factors may be operative; viz., cardiac failure, decreased renal function, excess salt-retaining steroids, excess antidiuretic hormone, serum electro...

Nephrotic syndrome is associated with up-regulation of the heparin-binding epidermal growth factor (HB-EGF). Erlotinib blocks the activation of the epidermal growth factor receptor (EGFR) in response to HB-EGF. This study investigates the effect of Erlotinib on the progression of proteinuria, renal dysfunction, and salt retention in doxorubicin treated nephrotic rats. Male rats were divided int...

An important property that has been extensively studied in quantitative structure activityrelationship (QSAR) is the chromatographic retention index. QSAR study is suggested for theprediction of retention index of alkanes and alkenes compounds. Modeling of the retention indexof alkanes and alkenes compounds as a function of molecular structures was established bydifferent chemometrics methods. ...