How human self-renewal tissues co-ordinate proliferation with differentiation is unclear. Human epidermis undergoes continuous cell growth and differentiation and is permanently exposed to mutagenic hazard. Keratinocytes are thought to arrest cell growth and cell cycle prior to terminal differentiation. However, a growing body of evidence does not satisfy this model. For instance, it does not e...

We report the first numerical demonstration of the generation of multiple superradiance pulses in a slippage-dominant freeelectron laser amplifier. In this simulation, the 1 and 2 multiple radiation-pulses are created from the deformation of the longitudinal phase space. Our simulation confirmed controllability over the temporal profile of these pulses, and paves the way for applying this techn...

This paper presents the measured energy losses in a draw gear with NE22, XH500, LL2, and CFG flat belts. The ranges of torque capacity, slippage occurrence, transmission efficiency selected drive belts are also presented. Knowing exact values these parameters allows selection most suitable for different applications. In addition, belt manufacturers do not provide data accurately, leading to mac...

Introduction: Slippage is usually measured with a standard manual method, however, if it required slippage information inline in extensive areas of cropland, mechanical and electronic equipment have to be developed. Objective: To design, assemble evaluate (in laboratory under field conditions) an encoder-based measurement system. Methodology: The system was integrated tested the laboratory, whe...

Genetically unstable expanded CAG·CTG trinucleotide repeats are causal in a number of human disorders, including Huntington disease and myotonic dystrophy type 1. It is still widely assumed that DNA polymerase slippage during replication plays an important role in the accumulation of expansions. Nevertheless, somatic mosaicism correlates poorly with the proliferative capacity of the tissue and ...

Mutations disrupting the function or production of C1 inhibitor cause the disease hereditary angioneurotic edema. Patient mutations identified an imperfect inverted repeat sequence that was postulated to play a mechanistic role in the mutations. To test this hypothesis, the inverted repeat was cloned into the chloramphenicol acetyltransferase gene in pBR325 and its mutation rate was studied in ...

The spacer between the 16S and 23S rRNA genes of the chloroplast DNA has been implicated as an origin of replication in several species of plants. In the evening primrose, Oenothera, this site was found to vary greatly in size, with plastid genomes (plastomes) being readily distinguished. To determine whether plastome "strength" in transmission could be correlated with variation at oriB, the 16...

We report the first experimental demonstration of a slippagedominant superradiant free-electron laser (FEL) using an ultrafast seed-laser pulse. We measured the evolution of the longitudinal phase space in the slippage-dominant superradiant regime. With a roughly 1% variation in the electron beam energy, we observed a seed-like fully longitudinal coherence, and a 2% wavelength shift from the se...

We consider the problems of kinematic and dynamic constraints, with actuator saturation and wheel slippage avoidance, for motion planning of a holonomic three-wheeled omni-directional robot. That is, the motion planner must not demand more velocity and acceleration at each time instant than the robot can provide. A new coupled non-linear dynamics model is derived. The novel concepts of Velocity...

Hydrophobic coatings, such as octadecyltrichlorosilane or n-alkyl monolayers, enhance the slippage of liquids on solid walls. For a given alkyl chain length, the main structural parameter for homogeneous coatings is the tilt angle between coating molecules and the surface normal. In this paper, ab initio calculations are used to calculate the equilibrium configuration of coating molecules, show...