Background. Recent studies suggest that adolescent adiposity is established already in preadolescence. Earlier studies have confirmed a strong tracking of obesity from adolescence to adulthood. Our aim was to examine the diagnostic accuracy of a population-derived protocol for identification of preschool children at risk for obesity in preadolescence. Methodology/ Principal Findings. We analyse...

The GEDI will support research using existing research samples to investigate main effects, correlations , and interactions among genetic, environmental , and developmental factors in the etiology of substance abuse and related phenotypes in humans. The term "substance abuse" as used in this RFA refers broadly to several different but related concepts including substance use (quantity, frequenc...

Background: Predicting intrinsically disordered proteins is important in structural biology because they are thought to carry out various cellular functions even though they have no stable three-dimensional structure. We know the structures of far more ordered proteins than disordered proteins. The structural distribution of proteins in nature can therefore be inferred to differ from that of pr...

for the Environment has created the Environmental Fellows program to enable recent doctorate recipients to use and expand Harvard's extraordinary resources to tackle complex environmental problems. The Environmental Fellows will work for two years with Harvard faculty members in any school or department to create new knowledge while also strengthening connections across the university's academi...

Background: Although sentinel lymph node (SLN) biopsy is a standard of care for the evaluation of the axillary lymph nodes during breast cancer surgery, a substantial degree of variation exists among individual surgeons as to what represents an adequate assessment. The aim of the current study was to assess when metastatic disease was first identified within consecutively harvested SLN candidat...

1 Epilepsy Center, University Hospital Freiburg, Freiburg, Germany, 2 Heidelberg Academy of Science and Humanities, Heidelberg, Germany, 3 Freiburg Brain Imaging, University Hospital Freiburg, Freiburg, Germany, 4 Bernstein Center for Computational Neuroscience Freiburg, Freiburg, Germany, 5 Neurobiology and Animal Physiology, Institute for Biology I, University of Freiburg, Freiburg, Germany, ...

The levels of mRNA for transforming growth factors (TGF alpha and beta) and the epidermal growth factor receptor (EGFR) were determined in 69 human breast carcinomas and 20 biopsies of nonneoplastic breast tissue by dot blot hybridisation analysis. TGF alpha mRNA was detected in 42% of cancers and 44% of non-neoplastic breast tissue at low levels. TGF beta mRNA was found in all breast cancers a...