The distribution of effects of beneficial mutations is key to our understanding of biological adaptation. Yet, empirical estimates of this distribution are scarce, and its functional form is largely unknown. Theoretical models of adaptation predict that the functional form of this distribution should depend on the distance to the optimum. Here, we estimate the rate and distribution of adaptive ...

Rhinomanometry provides a means to quantify the nasal airway in terms of its conductive efficiency by use of the inverse or resistance to airflow. In samples of 21 male and 26 female subjects, nasal airway resistance was compared with a number of form measurements and the coefficients of correlation were calculated. Statistical significance was found in some of the relationships with nasal airw...

1 Studies conducted on natural host-pathogen metapopulations have revealed considerable diversity of host resistance phenotypes within populations. The resistance structure of non-infected populations has, however, been largely ignored and the role of among-population variation in resistance profiles in the dynamics of natural pathogen populations is poorly understood. 2 The Plantago lanceolata...

Neutral genetic structure of natural populations is primarily influenced by migration (the movement of individuals and, subsequently, their genes) and drift (the statistical chance of losing genetic diversity over time). Migration between populations is influenced by several factors, including individual behavior, physical barriers, and environmental heterogeneity among populations. However, dr...

The electrical sheet resistance between living cells grown on planar electronic contacts of semiconductors or metals is a crucial parameter for bioelectronic devices. It determines the strength of electrical signal transduction from cells to chips and from chips to cells. We measured the sheet resistance by applying AC voltage to oxidized silicon chips and by imaging the voltage change across t...

Emerging known and unknown pathogens create profound threats to public health. Platforms for rapid detection and characterization of microbial agents are critically needed to prevent and respond to disease outbreaks. Available detection technologies cannot provide broad functional information about known or novel organisms. As a step toward developing such a system, we have produced and tested ...

OBJECTIVE To determine whether providing a controlled resistance versus assistance to the paretic leg at the ankle during treadmill training will improve walking function in individuals poststroke. DESIGN Repeated assessment of the same patients with parallel design and randomized controlled study between 2 groups. SETTING Research units of rehabilitation hospitals. PARTICIPANTS Patients ...

Various properties of HfO2, such as hardness, corrosion, or electrical resistance, depend on the method and conditions deposition. In this work, a thorough comparison scarcely investigated mechanical HfO2 thin films deposited with different reactive magnetron sputtering process is presented. Four were sputtered in processes that varied plasma ignition (continuous sequential) target–substrate di...