Flow resistance in open channels determines the average flow velocity a river, with important implications for downstream and at-a-station hydraulic geometry sediment transport natural channels. However, steep mountain is challenging to understand predict due heterogeneous channel morphology spatially variable flow. Using double-averaging approach appropriate very rough channels, width, reach, ...

PURPOSE To create and characterize a physical Windkessel module that can provide realistic and predictable vascular impedances for in-vitro flow experiments used for computational fluid dynamics validation, and other investigations of the cardiovascular system and medical devices. METHODS We developed practical design and manufacturing methods for constructing flow resistance and capacitance ...

OBJECTIVES To investigate the causes of wide variations in reported effects of hemodilution on flow resistance of vascular beds. METHODS (a) In a meta-analysis of 28 prior studies, resistance values at hematocrits of zero (R0) and 0.45 (R0.45) were derived. Study design characteristics (presence of vasodilatory reserve or leukocytes, species, tissue, hemodiluent) were tested by ANOVA for thei...

Production and approval of trastuzumab (Herceptin®) for the treatment of metastatic breast cancer (MBC) was a millstone in antibody-based targeted therapy in the cancer treatment. However, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. The majority of patients who benefit from the drug...