other protein shows such multiplicity and diversity of functions as the tumor suppressor p53 [1,2]. Initially, the role of p53 as " the guardian of the cellular genome " was considered to be providing protection from progression to malignancy. This was mediated by its function as a transcription factor of the genes controlling cell cycle and apoptosis [3]. Subsequent studies have identified a l...

BACKGROUND Similar to tissue stem cells, primitive tumor cells in chronic myelogenous leukemia have been observed to undergo quiescence; that is, the cells can temporarily stop dividing. Using mathematical models, we investigate the effect of cellular quiescence on the outcome of therapy with targeted small molecule inhibitors. METHODS AND RESULTS According to the models, the initiation of tr...

The regulation of hematopoietic stem cells (HSCs) depends on the integration of the multiple signals received from the bone marrow niche. We show the relevance of the protein tyrosine phosphatase PTPN13 and β-catenin as intracellular signaling molecules to control HSCs adhesiveness, cell cycling, and quiescence. Lethally irradiated mice transplanted with Lin(-) bone marrow cells in which PTPN13...

Primary cilia are specialized, acetylated microtubule-based signaling processes. Cilium assembly is activated by cellular quiescence and requires reconfiguration of microtubules, the actin cytoskeleton, and vesicular trafficking machinery. How these components are coordinated to activate ciliogenesis remains unknown. Here we identify the microtubule acetyltransferase Mec-17 and myosin II motors...

A number of studies have revealed variability from neutron star low-mass X-ray binaries during quiescence. Such variability is not well characterized, or understood, but may be a common property that has been missed due to lack of multiple observations. One such source where variability has been observed is Aql X-1. Here, we analyse 14 Chandra and XMM–Newton observations of Aql X-1 in quiescenc...

Satellite cells (SCs) are myogenic stem cells required for regeneration of adult skeletal muscles. A proper balance among quiescence, activation and differentiation is essential for long-term maintenance of SCs and their regenerative function. Here we show a function of Pten (phosphatase and tensin homologue) in quiescent SCs. Deletion of Pten in quiescent SCs leads to their spontaneous activat...

In formal testing, the assumption of input enabling is typically made. This assumption requires all inputs to be enabled anytime. In addition, the useful concept of quiescence is sometimes applied. Briefly, a system is in a quiescent state when it cannot produce outputs. In this paper, we relax the input enabling assumption, and allow some input sets to be enabled while others remain disabled. ...

The quiescence of hematopoietic stem cells (HSCs) is critical for preserving a lifelong steady pool of HSCs to sustain the highly regenerative hematopoietic system. It is thought that specialized niches in which HSCs reside control the balance between HSC quiescence and self-renewal, yet little is known about the extrinsic signals provided by the niche and how these niche signals regulate such ...

During pregnancy, the muscular layer of the uterine wall known as the myometrium, which is composed mainly of smooth muscle cells, is maintained in a state of relative quiescence. A switch from myometrial quiescence to myometrial activation is required to establish uterine contractions during labor. Researchers have long been perplexed by the fact that the major prostaglandin produced by the ut...

In formal testing, the assumption of input enabling is typically made. This assumption requires all inputs to be enabled anytime. In addition, the useful concept of quiescence is sometimes applied. Briefly, a system is in a quiescent state when it cannot produce outputs. In this paper, we relax the input enabling assumption, and allow some input sets to be enabled while others remain disabled. ...