Autologous chondrocyte implantation (ACI) is a treatment option for full-thickness chondral, or osteochondral injuries that are painful, debilitating, and progressive. Goals of surgery and rehabilitation include replacement of damaged cartilage with hyaline or hyaline-like structure, maintained durability to withstand knee intraarticular forces over time with a productive level of function, and...

We evaluate widths and shifts of pionic atoms using a theoretical microscopical potential in which the pion decay constant fπ is changed by an in–medium density dependent one ( fπ(ρ)), predicted by different partial Chiral restoration calculations. We show that the results obtained for shifts and widths are worse than if this modification were not implemented. On the other hand, we argue that i...

A 37 year old female patient presented with the clinical picture of pulmonary edema while pregnant (13 weeks). Eight years earlier she underwent mitral valve replacement because of rheumatic mitral incompetence using bileaflet StJude prosthesis. Her oral anticoagulation maintenance therapy (Coumadin) was discontinued by her physician and shifted to subcutaneous unfractionated heparin 10 days pr...

Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenitally deaf due to loss of glutamate release at the inner hair cell afferent synapse. Cochlear delivery of VGLUT3 using adeno-associated virus type 1 (AAV1) leads to transgene expression in only inner hair cells (IHCs), despite broader viral uptake. Within 2 weeks of AAV1-VGLUT3 delivery, auditory brainstem response (ABR) thr...

Implant therapy is now well established, and there is an increasing need for shorter rehabilitation time. Original prerequisites of osseointegration have been reassessed to satisfy continuously increasing patient's expectation of reduced treatment time, improved esthetics, and increased comfort. Shorter healing time may be appropriate in some circumstances, and examples of early loading have be...

The Dental profession has devoted most of its history to restoring the effects of dental disease. The public's interest in Dental health and beauty has become an engine that continues to drive the demand for cosmetic dental procedures. In the past, achieving a beautiful smile required submission to extensive invasive procedures and expensive fixed dental prosthetic restorations. Advancements in...

The purpose of this article is to give the reader a better understanding of the complex restorative challenge in achieving true harmonization of the primary parameters in esthetics (i.e., color, shape, and texture) represented by the replacement of a single anterior tooth. The case presented demonstrates the restoration of a Class IV fracture taking esthetic consideration of the anatomic variat...

UNLABELLED The replacement of crowns and bridges is a common procedure for many dental practitioners. When correctly planned and executed, fixed prostheses will provide predictable function, aesthetics and value for money. However, when done poorly, they are more likely to fail prematurely and lead to irreversible damage to the teeth and supporting structures beneath. Sound diagnosis, assessmen...

The rd1 mouse with a mutation in the Pde6b gene was the first strain of mice identified with a retinal degeneration. However, AAV-mediated gene supplementation of rd1 mice only results in structural preservation of photoreceptors, and restoration of the photoreceptor-mediated a-wave, but not in restoration of the bipolar cell-mediated b-wave. Here we show that a mutation in Gpr179 prevents the ...

Surgical voice restoration with a tracheo-oesophageal fistula using an alloplastic voice prosthesis is the current standard in Germany for patients with laryngectomy. With the increasing widespread use of this type of rehabilitation new duties emerge, not only for ones colleagues in the hospital but also for those in general practice. Care of these patients close to their home must be the aim o...