Time-restricted feeding (TRF) initiated early during the dark phase prevents metabolic consequences of a high-fat diet in rodent models. However, delaying initiation TRF, akin to breakfast skipping humans, is unclear. We assigned 8-week-old male C57BL/6J mice ( n = 192) chow or ad libitum (AL) for 4 weeks, before randomization continue AL 10 h at lights off (TRFe) 4-h after (TRFd) further 8 wee...
