BACKGROUND Trials report a 2% to 6% incidence of reinfarction after fibrinolysis for acute myocardial infarction (MI). We combined the Global Utilization of Streptokinase and Tissue plasminogen activator (alteplase) for Occluded coronary arteries (GUSTO I) and Global Use of Strategies To Open occluded coronary arteries (GUSTO III) populations to better define frequency, timing, and clinical pre...

UNLABELLED In India, the prevalence of ST elevation myocardial infarction (STEMI) is rising exponentially leading to cardiovascular morbidity and mortality. Despite advancement in reperfusion therapy (pharmacologic and interventional), the overall utilization, system of care and timely reperfusion remains suboptimal. JUSTIFICATION AND PURPOSE: Alarming treatment delays exist in patients present...

AFRICA 51 Editorial acute ischaemic stroke: highlighting the need for early intervention If only the brain was like the heart where losing a 'bit' from ischaemia and infarction would have little effect on its function, the treatment of stroke in the acute setting would not be such a public health issue. The effects of stroke on an individual and the burden its leaves on families and society are...

According to the guidelines of the European Stroke Organization (ESO) and the American Stroke Association (ASA), acute stroke patients should be managed at stroke units that include well organized pre- and in-hospital care. In ischemic stroke the restoration of blood flow has to occur within a limited time window that is accomplished by fibrinolytic therapy. Newer generation thrombolytic agents...

OBJECTIVE To review the recent advances in management of acute venous thromboembolism. DATA SOURCES Articles and published reviews on venous thromboembolism, pulmonary embolism and deep vein thrombosis. SUMMARY OF REVIEW Acute venous thromboembolism describes a group of disorders that include venous thrombosis (usually deep vein thrombosis) and pulmonary thromboembolism. Ultrasound suppleme...

In the year 2006, the results published in Circulation, with data from the National Registry of Myocardial Infarction, showed the need for reassuring the best strategy of revascularization following an episode of acute ST-segment elevation myocardial infarction (STEMI).1 Primary angioplasty improved outcomes compared with fibrinolysis in the cases of shorter needle-to-balloon time, decreasing i...

For more than a decade, intravenous thrombolytic therapy has been validated for the reduction of mortality in evolving MI. Reperfusion therapy is the standard of care for patients with acute MI who present early (within 12 hours of symptom onset) and have significant ECG STsegment elevation. However, the limitations of the therapy are especially impressive. First, even the most potent establish...

SUMMARY: The off-label use of drugs and devices in neuroendovascular procedures is common. Neurointerventionalists should be well aware of the level of evidence available in support of the off-label use of drugs and devices in their practice and some of the potential adverse events associated with them. These uses are categorized as I or II if they have been evaluated as primary or ancillary in...

A prospective interventional study was carried out to compare the thrombolytic effect of streptokinase between diabetic and non-diabetic myocardial infarction patients. Out of 187 study subjects with acute ST segment elevation myocardial infarction, admitted at coronary care unit, 126 patients were nondiabetic and 61 patients were diabetic. Streptokinase was administered to all patients. Resolu...