PURPOSE To investigate whether postmenopausal hormone therapy (HT) increases retinal and ONH blood flow (BF) and protects ONH topography and the function of retinal ganglion cells in postmenopausal women (PMW). The effect of estradiol (E(2)) treatment on retinal tissue perfusion was also investigated in ovariectomized rats, an animal model for menopause. METHODS Sixty-four healthy PMW were re...

PURPOSE To measure the retinal nerve fiber layer thickness in patients with pigment dispersion syndrome (PDS) using scanning laser polarimetry and to compare these measurements with those of normal subjects and patients with pigmentary glaucoma (PG). METHODS Age-, sex-, and refractive error-matched subjects--18 patients with PDS, 18 patients with PG, and 20 healthy subjects--were evaluated by...

Methods: Optical coherence tomographic images from 60 subjects (20 with ODE, 20 with ONHD, and 20 control subjects) were assessed qualitatively and quantitatively. Qualitative criteria for ODE included an elevated optic nerve head with smooth internal contour and subretinal hyporeflective space (SHYPS) with recumbent “lazy V” pattern. Optic nerve head drusen displayed a “lumpybumpy” internal op...

Wedge shaped defects of the retinal nerve fiber layer (RNFL) may occur in glaucoma. Currently, automatic detection of wedge shaped defects in Scanning Laser Polarimetry images of the retinal nerve fiber layer is unavailable; an automatic classification is currently based only on global parameters, thereby ignoring important local information. Our method works by a modified dynamic programming t...

The advent of optical coherence tomography angiography (OCT-A) provides a new opportunity to visualize the retinal vasculature in a non-invasive and dye-free manner which may help identify vascular abnormalities in glaucoma. While a reduction in retinal and optic nerve head vessel densities and blood flow indexes measured by OCT-A has been demonstrated in patients with glaucoma in many studies,...

The juxtapapillary diameters of the superior temporal and inferior temporal retinal artery and vein have been shown to be significantly smaller in glaucomatous eyes than in normal eyes. They had been measured in 473 eyes of 281 patients with chronic primary open-angle glaucoma and in 275 eyes of 173 normal subjects. In the current study the vessel diameters were correlated with intra- and parap...

PURPOSE To develop a software algorithm to perform automated segmentation of retinal layer structures on linear macular optical coherence tomography (StratusOCT; Carl Zeiss Meditec, Inc., Dublin, CA) scan images and to test its performance in discriminating normal from glaucomatous eyes in comparison with conventional circumpapillary nerve fiber layer (cpNFL) thickness measurement. METHODS Fo...

Aim: Glaucoma is an optic neuropathy and glaucomateus damage proceeds from retinal ganglion cells to brain. A better understanding of retrobulbar damage will enable us to develop more efficient strategies and a more accurate understanding of glaucoma. We evaluated retrobulbar glaucomatous damage with favorable techniques for 1.5T MR imaging. Material and methods: Five glaucoma cases and one hea...

Introduction Retinal astrocytic hamartomas are benign tumors of the retinal nerve fiber layer with a characteristic appearance on ophthalmoscopic examination. Although these lesions may be found in isolation without systemic involvement, they usually occur in association with tuberous sclerosis. To our knowledge, there are few reports presenting optical coherence tomography(OCT)findings of vitr...