Retinopathy of prematurity (ROP) is a proliferative disorder of the developing retina in premature and low birth weight infants. Recently, the role of vascular endothelial growth factor (VEGF) in the pathophysiology of ROP has been well studied and anti-VEGF drugs have been used in phase 2 to treat ROP patients in many ways. At first, ophthalmologists began to give intravitreal bevacizumab (IVB...

It is important to classify retinopathy of prematurity (ROP) in each eye, at each screening session. Doing so makes it possible to screen babies consistently and to make decisions about whether further screening is required and when, or whether laser treatment or surgical management is needed. The International Committee for the Classification of ROP1 has classified it using the following crite...

purpose: to determine the association between norrie disease (nd) gene mutations and advanced stages of retinopathy of prematurity (rop) in premature neonates who were referred to farabi eye hospital, tehran, iran during 2005-2007. methods: fifty infants including 28 male and 22 female subjects with rop stage 3 or worse were enrolled in this case series. all three exons of nd gene underwent pol...

OBJECTIVES This study evaluated the incidence and risk factors for severe retinopathy of prematurity (ROP) in babies <1000 g at Porto Alegre, Brazil. METHODS Prospective cohort study including premature children with birth weight ≤1000 g was conducted. Main outcome was the occurrence of severe ROP needing treatment. RESULTS A total of 157 infants were included. Severe ROP occurred in 20 inf...

Retinopathy of prematurity (ROP) is a vasoproliferative retinal disorder that continues to be the major cause of preventable childhood blindness worldwide. Its incidence is inversely proportional to gestational age and birth weight. Approximately 65 percent of neonates with <1,250 g birth weight and 80 percent of those with 1,000 g birth weight will develop some degree of ROP. ROP can cause mil...

Objective: Retinopathy of prematurity (ROP) is a blinding disease, initiated by the lack of retinal vascular growth after preterm birth. In Vitro, lack of insulin-like growth factor I (IGF-I) prevents normal retinal vascular growth. The present study was conducted to determine if low serum IGF-I levels in premature infants is associated with a higher incidence of retinopathy and therefore may b...

The aim of this study was to identify the factors influencing duration spontaneous regression Retinopathy Prematurity. A prospective observational conducted over a 1.5 years from December, 2019 May, 2021. All infants presenting with ROP or developed any stage later were considered for and followed up as per International Classification Guidelines (ICROP), 2005 guidelines till compete vascularis...

Retinopathy of prematurity (ROP) remains a leading cause of childhood blindness, affecting infants born prematurely. ROP is characterized by the onset of delayed physiological retinal vascular development (PRVD) and followed by pathologic neovascularization into the vitreous instead of the retina, called intravitreal neovascularization (IVNV). Therefore, the therapeutic strategy for treating RO...

AIM To describe incidence, co-morbidity characteristics, and risk factors associated with threshold retinopathy of prematurity (ROP) in survivors with a gestational age (GA) of < or =26 weeks at birth. METHODS Retrospective analysis of perinatal data of all inborn survivors in all perinatal centres of Belgium in the period 1999-2000 (EpiBel cohort) believed to be between 22 and 26 weeks GA at...

The courses of spherical equivalent in patients (n = 62) who had mild, non-cicatricial retinopathy of prematurity (ROP), and in those without a history of ROP (n = 25) were modeled as a linear function of age; an exponential model was also considered. A few (n = 5) without ROP have abnormal courses characterized by hyperopia in early infancy; none have poor acuity. Although the majority of pati...