A feasibility study was performed to compare an investigational drug, HBN-1, to forced cooling to induce hypothermia after resuscitation in a translation model of asphyxial cardiac arrest in swine. Serum and cerebral spinal fluid neuron-specific enolase activity (sNSE and csfNSE) were measured after cardiac arrest as surrogate markers of brain injury. In a block design, swine resuscitated from ...

Abstract Background Status epilepticus (SE) is a common complication in patients surviving cardiac arrest, but little known about the frequency of nonconvulsive status (NCSE). Objectives To compile first evidence from literature overall NCSE adults with persistent coma following arrest. Secondarily, to assess emergence comatose resuscitated within hours return spontaneous circulation (ROSC) and...

INTRODUCTION Most studies have analyzed pre-arrest and resuscitation factors associated with mortality after cardiac arrest (CA) in children, but many patients that reach return of spontaneous circulation die within the next days or weeks. The objective of our study was to analyze post-return of spontaneous circulation factors associated with in-hospital mortality after cardiac arrest in childr...

Use of mild therapeutic hypothermia to goal 32 34 °C, after return of spontaneous circulation (ROSC) in cardiac arrest patients, has been shown to increase the rates of survival and favorable neurological outcomes [1, 2]. The American Heart Association (AHA) recommends mild therapeutic hypothermia after ROSC for out-of-hospital cardiac arrest with an initial documented rhythm of ventricular fib...

BackgroundCardiopulmonary resuscitation (CPR) in the delivery room (DR) after birth is rare. We hypothesized that factors related to maternal, delivery, infant and event characteristics associated with outcomes could be identified. also there would substantial variation from Neonatal Resuscitation Program (NRP) algorithm.MethodsRetrospective review of all neonates receiving chest compressions D...

Patients receiving cardiopulmonary resuscitation (CPR) may rarely experience resuscitation-induced consciousness (CPRIC), manifesting as body movements, eye-opening, or even awareness. We present a case report of 55-year-old male patient who experienced CPRIC but did not survive despite resuscitative measures. The suffered sudden cardiac arrest and received early initiation CPR. However, posed ...

BACKGROUND Blood pressure is severely reduced in patients in cardiac arrest receiving standard cardiopulmonary resuscitation (CPR). Although active compression-decompression (ACD) CPR improves acute hemodynamic parameters, arterial pressures remain suboptimal with this technique. We performed ACD CPR in patients with a new inspiratory threshold valve (ITV) to determine whether lowering intratho...

Interposed abdominal compression (IAC)-CPR includes all steps of standard external CPR with the addition of manual mid-abdominal compressions in counterpoint to the rhythm of chest compressions. IAC-CPR can increase blood flow during CPR about two fold compared to standard CPR without IAC, as shown by multiple studies in computer and animal models. The technique increases the rate return of spo...