The mammalian TOR (mTOR) pathway is a key regulator of cell growth and proliferation and increasing evidence suggests that its deregulation is associated with human diseases, including cancer and diabetes. The mTOR pathway integrates signals from nutrients, energy status and growth factors to regulate many processes, including autophagy, ribosome biogenesis and metabolism. Recent work identifyi...

The activity of mammalian target of rapamycin complex 1 (mTORC1) is frequently enhanced in carcinomas, an effect thought to contribute to the malignant phenotype. Here, it is demonstrated that either deletion or mutation of TP53 in colon or lung carcinoma cells substantially enhances mTORC1 kinase activity by an effect downstream of and independent of AMPK. Mechanistically, it was determined th...

Growth factors and nutrients regulate the mechanistic target of rapamycin complex 1 (mTORC1) by different mechanisms. The players that link growth factors and mTORC1 activation have been known for several years and mouse models have validated its relevance for human physiology and disease. In contrast to the picture for growth factor signaling, the means by which nutrient availability leads to ...

each stream ecosystem may be impacted by land use and intensified human expansion. According to the fall macrobenthic results, nearly all sites saw an increase in %EPT, except for Massaponax 208 and Ni Route 1. Even though both Massaponax Creek and the Ni River are under EPA legal limits for phosphate and nitrate concentrations, the phosphate levels usually rose in summer on the Massaponax and ...