Pioneering wet lab experiments have already established the role of mitochondria as a power house inside the cell. Apart from that this organelle has important role in several other cellular processes like calcium signalling, apoptosis, embryonic and tissue development, lipid synthesis, aging etc. Here in the present study the focal theme has set on the role of this organelle towards developmen...

Melanoma cells exhibit numerous transcriptional cell states including developmental programs such as neural crest-like and pigmented melanocytic cells. These endow tumorigenic properties like sustained growth, immune evasion, therapy resistance, metastasis. Here, we use a zebrafish melanoma model to identify program linking the state dependence on lipid droplets, specialized organelle responsib...

A subset of cellular compartments maintain acidic interior environments that are critical for the specific functions of each organelle and for cell growth and survival in general. The pH of each organelle reflects the balance between proton pumping, counterion conductance, and proton leak. Alterations in steady-state organelle pH due to defects in either proton pumping activity or counterion co...

Immunological homology between chloroplast ribosomal proteins (r-proteins) from a higher plant (Spinacia) and bacterial r-proteins was examined using antibodies prepared against 35 purified Escherichia coli r-proteins. Cross-reactions were determined on cellulose acetate gels and on nitrocellulose paper, after electrophoretic transfer of r-proteins from one- and two dimensional polyacrylamide g...

Organelle genomes are widely thought to have arisen from reduction events involving cyanobacterial and archaeal genomes, in the case of chloroplasts, or α-proteobacterial genomes, in the case of mitochondria. Heterogeneity in base composition and codon preference has long been the subject of investigation of topics ranging from phylogenetic distortion to the design of overexpression cassettes f...

Mycoplasma pneumoniae is a major cause of bronchitis and atypical pneumonia in humans. This cell wall-less bacterium has a complex terminal organelle that functions in cytadherence and gliding motility. The gliding mechanism is unknown but is coordinated with terminal-organelle development during cell division. Disruption of M. pneumoniae open reading frame MPN311 results in loss of protein P41...

Amplification of RNA from human sperm heads yielded a fragment of 435 bp that shares 100% identity with a central region of the 16S mitochondrial rRNA. The nuclear localization in the sperm of the mitochondrial RNA was confirmed by in-situ hybridization. These results, together with the localization of the 16S mitochondrial rRNA in mouse sperm, are the first demonstration that the organelle tra...

Chloroplasts and their nonphotosynthetic relatives in the plastid organelle family evolved from a cyanobacterial endosymbiont (for review, see Timmis et al., 2004). The subsequent coevolution of the chloroplast and nuclear genomes produced an organelle that is eubacterial at its core but with extensive chloroplastspecific embellishments. Of the thousands of genes in the cyanobacterial ancestor,...

Organelle movement in plants cells is extremely dynamic. Movement is driven by the acto-myosin system. Higher plant myosins fall into two classes: classes XI and VIII. Localization studies have highlighted that myosins are present throughout the cytosol, label motile puncta and decorate the nuclear envelope and plasma membrane. Functional studies through expression of dominant-negative myosin v...

Why the DNA-containing organelles, chloroplasts, and mitochondria, are inherited maternally is a long standing and unsolved question. However, recent years have seen a paradigm shift, in that the absoluteness of uniparental inheritance is increasingly questioned. Here, we review the field and propose a unifying model for organelle inheritance. We argue that the predominance of the maternal mode...