Fraser, Jaco, Yendt, Munn and Liu (1957) and Fraser, Geiger, Munn, Slater, Jahn and Liu (1958) reported healing of rachitic lesions in vitamin Ddeficient and in hypophosphataemic refractory rickets by intravenous administration of phosphate. The concentration of serum inorganic phosphorus, which initially had been very low, was kept at normal levels for a period of five to seven days. The autho...

OBJECTIVE To determine the occurrence of subclinical rickets and its causing factors among adolescent students of schools in Kaghan Valley, Pakistan. STUDY DESIGN Observation cross-sectional study. PLACE AND DURATION OF STUDY Department of Biochemistry and Health Sciences, Hazara University, Mansehra, Ayub Medical College and Teaching Hospital, Abbottabad, from March to April 2012. METHOD...

Little has been added to the knowledge of the treatment of renal rickets since the paper by Graham and Oakley (1938), and the reader is referred to their work for a summary of the previous literature of this condition. Whether or not in fact rickets is the principal bony lesion has been questioned by Langmead and Orr (1933). From a morbid anatomical study, they concluded that osteitis fibrosa w...

Nutritional rickets in Nigerian children has been effectively treated with Ca supplementation. High values of Ca absorption efficiency have been observed in untreated children, but whether Ca absorption efficiency changes during treatment with Ca is unknown. Our objective in conducting this study was to identify the effect of Ca therapy on Ca absorptive efficiency in children with primary Ca-de...

Primary de Toni-Debré-Fanconi syndrome is a non-FGF23-mediated hypophosphatemic disorder due to a primary defect in renal proximal tubule cell function resulting in hyperphosphaturia, renal tubular acidosis, glycosuria, and generalized aminoaciduria. The orthopaedic sequela and response to treatment of this rare disorder are limited in the literature. Herein we report a long term followup of a ...

PURPOSE OF REVIEW Nutritional rickets and osteomalacia are common in dark-skinned and migrant populations. Their global incidence is rising due to changing population demographics, failing prevention policies and missing implementation strategies. The calcium deprivation spectrum has hypocalcaemic (seizures, tetany and dilated cardiomyopathy) and late hypophosphataemic (rickets, osteomalacia an...

X-linked hypophosphatemia (XLH) is a rare type of hereditary hypophosphatemic rickets. Patients with XLH have various symptoms that lower their QOL as defined by HAQ, RAPID3, SF36-PCS, and SF36-MCS in adult patients SF-10 PDCOI pediatric patients. Early diagnosis treatment are needed to reduce the burden, but condition often diagnosed late childhood. The present review aims summarize symptoms, ...

OBJECTIVE The purpose of this study was to review the hypothesis that classic metaphyseal lesions represent traumatic changes in abused infants and compare these lesions with healing rickets. MATERIALS AND METHODS Using a PubMed search, a multidisciplinary team reviewed studies that reported the histopathologic correlation of classic metaphyseal lesions. Selective studies of growth plate inju...

background: tyrosinemia type 1 is an autosomal recessive metabolic disorder, which typically affects liver and kidneys. it is caused by a defect in fumarylacetoacetate hydrolase or fumarylacetoacetase (fah) enzyme, the final enzyme in the tyrosine degradation pathway. the disease typically manifests as early onset type in early infancy with acute hepatic crisis with hepatomegaly and bleeding te...

backgroundrickets is a disorder due to impaired metabolism of bone mineralization which caused by low concentrations of extra-cellular calcium or phosphate. in children, hypophosphatemic rickets (hr) happen malabsorption of phosphate and increasing of renal tubular loss.case presentation we present the case of a 4-year-old girl who had medical history of hr with failure to thrive (ftt). child h...