background sepsis can be defined as the body’s response to an infection. sepsis in children remains a significant cause of morbidity and mortality worldwide. objectives this study focuses on the etiological factors, risk factors, and clinical characteristics of sepsis in neonate and pediatric patients. patients and methods a prospective study was conducted over a six-month period in the pediatr...

ranging from 0.15 to 0.84). Stratification by age of AD onset (using 65 years as cutoff) or APOE ε4-genotype did not appreciably change these results (data not shown; stratified analyses were not possible in the GWAS samples as no onset age or APOE ε4 data were supplied). Effect size estimates indicated insignificant ORs that were opposite in direction to those reported by Dreses-Werringloer et...

Low-levels of dioxin cause cancer in animals. In 1997 dioxin was found to be a human carcinogen by the International Agency for Research on Cancer, based largely on four studies of industrial workers exposed to high levels. Recently there has been interest in estimating human cancer risk at low level environmental exposures. Here we review quantitative exposure-response analyses and risk assess...

Many engineering systems represent challenging classes of complex dynamic systems. Lacking information about their system properties leads to model uncertainties up to a level where quantification of uncertainties may become the dominant question in modeling, simulation and application tasks. Uncertainty quantification is the prerequisite for probabilistic risk assessment and related tasks. Cur...

The scale of the current outbreak of Ebola virus disease in west Africa is staggering. Thousands of infections and deaths have been reported in recent months, and unless major changes occur in the situation, incidence of Ebola virus disease has been projected to continue to grow and cumulative incidence to exceed 20 000 by November. A humanitarian crisis that stretches far beyond the impact of ...

Risk analysis has been used to manage the security of systems for several decades. However, its use has been limited to offline risk computation and manual response. In contrast, we use risk computation to drive changes in an operating system’s security configuration. This allows risk management to occur in real time and reduces the window of exposure to attack. We posit that it is possible to ...

In this issue of Blood, Palladini and colleagues address incidence of and risk factors for end-stage renal disease (ESRD) and proffer a new renal response system for patients with amyloid light-chain (AL) amyloidosis using a test set of 461 patients from Pavia, Italy, and a validation set of 271 patients from Heidelberg, Germany. Validation of organ response criteria has trailed behind the prog...

that neither the exact nor the approximate solution describes cancer incidence data well, and that models incorporating cell proliferation kinetics do better. 4 Be that as it may, for any stochastic model, stochastic heterogeneity is immediately introduced if the stochastic solution is used. Inter-individual variations in susceptibility arising from variations in the rates of critical biologica...

Introduction: There are significant gender differences in the epidemiology and presentation of cardiovascular diseases (CVDs), physiological aspects of CVDs, response to diagnostic tests or interventions, and prevalence or incidence of the associated risk factors. Considering the independent influence of gender on early dire consequences of such diseases, this study was conducted to investigate...