Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the blood-brain barrier (BBB) during thrombolysis from rt-PA-induced damage. While the use of nonselective ROCK inhibitors like fasudil together with rt-PA may be hindered by possible hypotensive side-effects and inadequate capacity to block detrimental rt-PA activity in brain endothelial cells (BECs), selecti...

This research work presents a case study of rock mass characterization on diversion tunnels at Diamer Basha Dam, Pakistan. Geological and geotechnical studies were performed to characterize the rock mass along the axis of diversion tunnel. The core specimens retrieved were tested in laboratory and physical and mechanical properties of the rock mass were determined. Detailed discontinuity survey...

In underground tunnels or caverns, time-dependent deformation or failure of rock mass, such as extending cracks, gradual rock falls, etc., are a costly irritant and a major safety concern if the time-dependent damage of surrounding rock is serious. To understand the damage evolution of rock mass in underground engineering, an in situ experimental testing was carried out in a large belowground t...

Original scientific paper Rock generally contains various micro-cracks, fissures, pores, joints, and other defects. These defects affect the mechanical properties of rock. In order to clarify the influence of native fissures on rock deformation and failure modes, a laboratory study was carried out using the fissured dolomite, and acoustic wave velocity measurement and natural water absorption t...

Asymmetric dimethylarginine (ADMA) induces vascular smooth muscle cells (VSMCs) migration. VSMC phenotype change is a prerequisite of migration. RhoA and Rho-kinase (ROCK) mediate migration of VSMCs. We hypothesize that ADMA induces VSMC migration via the activation of Rho/ROCK signal pathway and due to VSMCs phenotype change. ADMA activates Rho/ROCK signal pathway that interpreted by the eleva...

Landslide in alpine regions often causes heavy losses of both human lives and properties, most of the landslides are induced by heavy rainfall. In this paper, we put forward an early warning system of rain-induced landslide. From 2002, we carried on the demonstrative work of landslide monitoring and early warning in Yaan, Sichuan Province, China, and constructed the first county-scale landslide...

rndetermination of rock mass deformation modulus is very important in different projects, especially in civil and mining engineering works. in-situ measurements such as dilatometer, plate load and flat jack methods may be applied to determine the deformation modulus. however, these methods are very expensive and time- consuming. analytical methods are very useful approaches which can also be us...

to determine the degree of susceptibility of an. sacharovi to malathion 5%, fenitrothion 1% and ddt 4% extended studies were carried out on sucked blood engorged mosquitoes collected from dasht argen (fars province) in 1997. testing method was according to standard who method in lots of 25 adults' mosquitoes in 4 replicates. an. sacharovi were touched by malathion 5% and ddt 4% insecticides in ...