Large dynamic on-resistance due to a trap at EC-2.0 eV is observed in industry-supplied AlGaN/GaN MISHEMTs. This trap is likely in the GaN buffer and possibly related to carbon. AlGaN/GaN metal-insulator-semiconductor high electron mobility transistors (MISHEMTs) for high voltage switching applications are promising due to the ability to simultaneously achieve high breakdown voltage and low on-...

PURPOSE The receptor tyrosine kinase RON is critical in epithelial tumorigenesis and a drug target for cancer therapy. Here, we report the development and therapeutic efficacy of a novel anti-RON antibody Zt/g4-maytansinoid (DM1) conjugates for targeted colorectal cancer (CRC) therapy. EXPERIMENTAL DESIGN Zt/g4 (IgG1a/κ) was conjugated to DM1 via thioether linkage to form Zt/g4-DM1 with a dru...

PURPOSE Recent studies have demonstrated that short-form Ron (sfRon) kinase drives breast tumor progression and metastasis through robust activation of the PI3K pathway. We reasoned that upfront, concurrent inhibition of sfRon and PI3K might enhance the antitumor effects of Ron kinase inhibitor therapy while also preventing potential therapeutic resistance to tyrosine kinase inhibitors (TKI). ...

Hyaluronan (HA) is synthesized in high-molecular-weight form at the apical pole of airway epithelial cells, covering the luminal surface. When human airway epithelial cells grown and redifferentiated at the air-liquid interface (ALI) were exposed to xanthine/xanthine oxidase (X/XO), ciliary beat frequency (CBF) increased. This effect was blocked by superoxide dismutase (SOD) and catalase. Inhib...

RON is a member of the c-MET receptor tyrosine kinase family. Like c-MET, RON is expressed by a variety of epithelial-derived tumors and cancer cell lines and it is thought to play a functional role in tumorigenesis. To date, antagonists of RON activity have not been tested in vivo to validate RON as a potential cancer target. In this report, we used an antibody phage display library to generat...

n vertebrate cells, not all potential DNA replication origins fire in each S phase, but it is unclear what parameters control that decision. Mauro Anglana, Michelle Debatisse (Institut Curie, Paris, France), and colleagues find that nucleotide availability can determine which origins are activated. Under normal conditions (when nucleotides were readily available), initiation occurred predominan...

A stepped split triple-gate SOI LDMOS with P/N strip (P/N SSTG LDMOS) is proposed, which has ultralow specific on-resistance (Ron,sp) and low switching losses. The proposed device a (TG) gates (SSGs). P strip, N-drift oxide trench are alternately arranged in the Z direction. Meanwhile, SSGs located of region distributed steps. Firstly, TG increases channel width (Wch) effect modulating current ...