Rosai-Dorfman Disease (RDD) or sinus histiocytosis with massive lymhadenopathy (SHML) is a rare, benign proliferative disorder of histiocytes characterized by painless bilateral cervical lymph node enlargement though extranodal disease involving skin, respiratory system, central nervous system (CNS) etc may been in > two third of cases (1-3). With lack of widespread awareness about this entity,...

56 PRACTICAL DERMATOLOGY AUGUST 2014 R osai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy (SHML) is a benign lympho-histiocytic proliferative disorder initially described with bilateral painless lymphadenopathy (90 percent), fever, leukocytosis, elevated ESR, anemia, and polyclonal hypergammaglobulinemia (90 percent).1 RDD presents with cervical adenopathy most comm...

BACKGROUND Rosai-Dorfman Disease is an uncommon benign systemic histio-proliferative disease. This is the first time the disease, although more common in people of African descent, is described in association with Sickle cell disease. CASE PRESENTATION A Nigerian boy born started a complex medical history with post-natal anemia of unknown origin. Subsequently he was diagnosed with Sickle Cell...