BACKGROUND Rotator cuff tendons heal to bone with interposed scar tissue, which makes repairs prone to failure. The purpose of this study was to determine if the application of bone marrow-derived mesenchymal stem cells (MSCs) can improve rotator cuff healing after repair. HYPOTHESIS Application of MSCs to the repair site will result in superior results compared with controls on histologic an...

BACKGROUND Recent investigation of human tissue and cells from positional tendons such as the rotator cuff has clarified the importance of inflammation in the development and progression of tendon disease. These mechanisms remain poorly understood in disease of energy-storing tendons such as the Achilles. Using tissue biopsies from patients, we investigated if inflammation is a feature of Achil...

BACKGROUND Despite the high prevalence of rotator cuff disease in the aging adult population, the basic mechanisms initiating the disease are not known. It is known that changes occur at both the bone and tendon after rotator cuff tears. However, no study has focused on early or "pretear" rotator cuff disease states. The purpose of this study was to compare the bone mineral density of the great...

BACKGROUND The incidence of asymptomatic rotator cuff tears has been reported to range from 15% to 39%, but the influence of asymptomatic rotator cuff pathology on shoulder function is not well understood. This study assessed the effects of asymptomatic rotator cuff pathology on shoulder kinematics, strength, and patient-reported outcomes. METHODS A clinical ultrasound examination was perform...

Background: Shoulder joint pain is commonly seen in primary care. Were many of them diagnosed with rotator cuff disease especially involvement of supraspinatus tendon of rotator cuff. The progression of disease leads to tear of rotator cuff and the etiology is multifactorial. However, characteristic changes of acromion morphology appear as major risk factor for rotator cuff tear. According to a...

Magnetic resonance imaging makes it possible to inspect the status of the rotator cuff and the shape of the acromion. To clarify the relationship between acromial shapes and rotator cuff tears, we evaluated magnetic resonance images obtained in 192 shoulders. We classified the acromial shapes into 3 types: type I (flat), type II (curved), and type III (hooked). Among a group of 91 shoulders wit...

BACKGROUND Rotator cuff repair retear rates range from 25% to 90%, necessitating methods to improve repair strength. Although numerous laboratory studies have compared single-row with double-row fixation properties, little is known regarding regional (ie, medial vs lateral) suture retention properties in intact and torn tendons. HYPOTHESIS A torn supraspinatus tendon will have reduced suture ...

Musculoskeletal disease is one of the most common complications in patients with diabetes, and yet is receives relatively little attention. The severity and the risks of musculoskeletal complications might not be well recognized as cardiovascular complications; however, the associated ailments certainly inflict both physical and psychological harm on people with diabetes. Among the various musc...

BACKGROUND In vivo studies showing the effects of biologic healing-promoting factors on tendon-to-bone healing after rotator cuff repair have focused only on biologic healing-promoting factors and have not taken into consideration the effect of the carrier vehicle. Moreover, most studies have evaluated the healing process using different carrier vehicles, each of which may have specific effects...