Background: Several study suggested body mass index(BMI) may influence development of rheumatoid arthritis(RA). There are conflicting reports concerning the impact high BMI on RA, but several obese drug resistance and functional impairment. The relationship genetic polymorphism obesity is unclear in RA. Objectives: To examine among BMI, obesity, disease activity laboratory parameters, therapeut...

According to the World Health Organization, the worldwide prevalence of childhood overweight and obesity increased from 4.2% in 1990 to 6.7% in 2010 and it is expected to reach 9.1% in 2020 (1). This is alarming because BMI in childhood is associated with type 2 diabetes, hypertension, coronary heart disease, and mortality in adulthood (2). The obesity epidemic is no longer merely a problem in ...

Obesity is recognized as a major health problem worldwide. Genetic factors play a major role in obesity, and genomewide association studies have provided evidence that several common variants within the fat mass- and obesity-associated (FTO) gene are significantly associated with obesity. Very limited data is available on FTO in the Italian population. Aims of our study are to investigate: (1) ...

BACKGROUND Obesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotide-polymorphisms (SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. The aim of this study was to investigate SNPs rs8050136, rs9939609, and rs1421085 of the FTO gene in women with GDM and their associations with maternal pre-pregnancy weight and b...

AIM We tested the hypothesis that the obesity-associated FTO SNP rs9939609 would be associated with clinically significant weight gain (≥ 5% of initial body weight) in the first year of university; a time identified as high risk for weight gain. METHODS We collected anthropometric data from university students (n = 1,411, mean age: 22.4 ± 2.5 years, 49.1% male) at the beginning and end of the...

Previous studies have examined the association between the fat mass and obesity-associated (FTO) gene variant and risk of cancer in diverse populations. However, the results have been inconsistent. PubMed and Embase databases were searched for the eligible publications in English language by July, 2016. The associations of FTO variants with cancer risk were estimated by calculating the pooled o...

PURPOSE We evaluated the association between risk of obesity in the Portuguese population and two obesity-related single-nucleotide gene polymorphisms: fat-mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma (PPARG) rs1801282. PATIENTS AND METHODS A total of 194 Portuguese premenopausal female Caucasians aged between 18 and 50 years (95 with body m...