Negative and positive symptoms were determined for 46 drug-free patients who met Research Diagnostic Criteria (RDC) and/or Feighner criteria for schizophrenia. A modified version of the Scale for the Assessment of Negative Symptoms (SANS) was completed for each patient based on items from the Schedule for Affective Disorders and Schizophrenia (SADS) and other scales. Positive symptoms were scor...

BACKGROUND Tobacco use prevention programmes need accurate information about smoking related mortality. Beginning in 1989, Oregon began asking physicians to report on death certificates whether tobacco use contributed to the death. OBJECTIVE To determine the long term comparability of this method of estimating tobacco attributable mortality to estimates of smoking attributable mortality deriv...

Objective: Driving is a complex behavior and is affected by several factors. This cohort study aimed at representing the main determinants such as personality features, driving behavior, and mental illnesses on driving violation based on logistic regression. Method: In this cohort study, 800 heavy truck and lorry drivers were recruited. Participants were selected from those individuals who refe...

INTRODUCTION Children with cerebral palsy (CP), one of the most common childhood neurological disorders, often have associated medical and psychological symptoms. This study assesses mental health problems compared to population controls and the ability of a mental health screening tool to predict psychiatric disorders and to capture the complexity of coexisting symptoms. METHODS Children wit...

Some dogs can signal human seizure activity. Seizure response dogs (SRDs) recognize and respond to ongoing seizure and postseizure compromise, whereas seizure alert dogs (SADs) may warn of impending seizure.1-5 Canine companions may have an additional stress reduction benefit that can lead to decreased seizure frequency.5 In this report we describe a dog that warns of psychogenic nonepileptifor...

We propose a novel testing technique for object-oriented programs. Based on the state and activity models of a system, we construct an intermediate representation, which we have named state-activity diagram (SAD). We generate test cases to achieve state-activity coverage of SADs. We have empirically evaluated the effectiveness of our approach. The results show that the proposed technique could ...

OBJECTIVE The purpose of this study was to compare psychiatric comorbid disorders and psychological outcomes in children and adolescents with Attention-deficit/hyperactivity disorder (ADHD). METHODS Subjects were divided into a child group (aged under 12 years) and an adolescent group (aged 12 years and above). All subjects were diagnosed with ADHD based on the DSM IV diagnostic criteria usin...

Objective: To assess the influence of gender on familial transmission of ADHD. Methodology: Two hundred seventy seven probands with ADHD (aged 5-17 years) were screened with clinical interview and the schedule for affective disorders and schizophrenia for School – Age Children Present and Lifetime version (K – SADS – PL). Nine hundred ninty seven first degree relatives (554 parents, 443 sibling...

Candida species are the cause of 60% of all mycoses in immunosuppressed individuals, leading to ∼150,000 deaths annually due to systemic infections, whereas the current antifungal therapies either have toxic side effects or are insufficiently efficient. We performed a screening of two compound libraries, the Enzo and the Institute for Molecular Medicine Finland (FIMM) oncology collection librar...

BACKGROUND Reduction of P300 amplitude in children and adolescents at high risk for developing alcoholism has frequently been reported. It has been hypothesized that this reduction represents a developmental delay in reaching age-appropriate levels in P300 amplitude. Using latent growth analysis of longitudinal data obtained at yearly intervals, this study seeks to define normal growth, and det...