Sonic hedgehog (Shh) is a morphogenic protein that operates through the Gli transcription factor-dependent canonical pathway to orchestrate normal development of many tissues. Because aberrant levels of Gli activity lead to a wide spectrum of diseases ranging from neurodevelopmental defects to cancer, understanding the regulatory mechanisms of Shh canonical pathway is paramount. During early st...

We set out to demonstrate that the Rényi entropies with parameter α are better thought of as operating in a type of non-linear semiring called a positive semifield. We show how the Rényi’s postulates lead to Pap’s g-calculus where the functions carrying out the domain transformation are Renyi’s information function and its inverse. In its turn, Pap’s g-calculus under Rényi’s information functio...

Automation systems exist in many variants and may evolve over time in order to deal with different environment contexts or to fulfill changing customer requirements. This induces an increased complexity during design-time as well as tedious maintenance efforts. We already proposed a multiperspective modeling approach to improve the development of such systems. It operates on different levels of...

it is proved here that if $g$ is a locally graded group satisfying the minimal condition on subgroups which are not locally supersoluble, then $g$ is either locally supersoluble or a vcernikov group. the same conclusion holds for locally finite groups satisfying the weak minimal condition on non-(locally supersoluble) subgroups. as a consequence, it is shown that any infinite locally graded gro...

Multiple Glass Ceilings Both vertical (between job levels) and horizontal (within job levels) mobility can be sources of wage growth. We find that the glass ceiling operates at both margins. The unexplained part of the wage gap grows across job levels (glass ceiling at the vertical margin) and across the deciles of the intra-job-level wage distribution (glass ceiling at the horizontal margin). ...

in the analysis of spatial point patterns, complete spatial randomness (csr) hypothesis,which is a restriction of a homogenous poisson process to study region a, operates as a dividinghypothesis between “regular” and “aggregated” patterns. meanwhile, many alternatives to csr inaggregated patterns are extensions of homogenous poisson processes themselves. therefore, when thecsr hypothesis is rej...

One of the key issues for implementing congestion pricing is the pricing granularity (i.e. pricing interval or timescale). The Internet traffic is highly variant and hard to control without a mechanism that operates on very low time-scales, i.e. on the order of round-trip-times (RTTs). However, pricing naturally operates on very large timescales because of human involvement. Moreover, structure...