A fully enzymic reagent for determination of salicylate in serum has been developed for use in the Paramax analytical system. The assay, run as an equilibrium determination, is based on the reaction of salicylate with NADPH and oxygen in the presence of salicylate hydroxylase (EC 1.14.13.1) to form catechol, NADP+, carbon dioxide, and water. The reaction is complete within 7 min, after which ti...

Stress has an important role in the induction of gastroduodenal injury. It was reported that oxygen free radicals played a role in the pathogenesis of this injury. Although some other antioxidant compounds and calcium channel blockers were examined in ulcer models, salicylate has not been tested for its gastroprotective effect in ulcer models by now. In the present study, intraperitoneal admini...

The most common mechanism of antibiotic resistance in multiply resistant Pseudomonas cepacia is decreased porin-mediated outer membrane permeability. In some gram-negative organisms this form of antibiotic resistance can be induced by growth in the presence of weak acids, such as salicylates, which suppress porin synthesis. To determine the effects of salicylates on outer membrane permeability ...

BACKGROUND Intake of aspirin is associated with reduction in risk of colorectal adenoma and carcinoma. Some plants contain salicylates, and individuals not taking aspirin may have measurable salicylate levels. However, the association between serum salicylate level and recurrence of adenoma in nonusers of aspirin has not been studied. METHODS We measured serum salicylate levels in participant...

Salicylate is the major metabolite and active component of aspirin (acetylsalicylic acid), which is widely used in clinical medicine for treating inflammation, pain syndromes and cardiovascular disorders. The well-known mechanism underlying salicylate's action mainly involves the inhibition of cyclooxygenase and subsequent decrease in prostaglandin production. Recent evidence suggests that sali...

The term ‘bio-regulator’ has been used to encompass the natural and synthetic compounds that regulate various plant growth developmental processes. Plant bio-regulators (PBRs) previously called regulators. Use of PBRs with a unique fact finding support assistance from biotechnology made new approach manipulating biological activities for enhancing growth, yield, quality, nutritive value an impo...

This paper is aimed to estimate the transmittance of electronic effects in fluorescein molecule between phthalic acid residue and xanthene moiety. Despite almost orthogonal orientation latter with respect rest molecule, some influence substituents this 9-aryl ring on dissociation hydroxyl group hydroxyxanthene cannot be ruled out. In order reveal (possible) effect, we blocked carboxylic via est...

Corrosion protection and surface properties of Magnesium (Mg) containing 51 ppm Fe (HP-Mg) 341 (CP-Mg) were assessed by EIS, AFM/SKPFM, photoluminescence spectroscopy in NaCl solutions with/without fumarate (Fum), 2,5-pyridinedicarboxylate (PDCA) salicylate (Sal) carboxylates. The PDCA was effective corrosion inhibition HP-Mg CP-Mg, while the Sal efficient CP-Mg only. Volta potential (VPD) chan...

Salicylates provide the backbone of therapy in juvenile rheumatoid arthritis. They are effective in controlling the disease approximately 75% of the time if they are properly used. Salicylate administration is relatively safe if carefully done. Serum salicylate levels should not exceed 30 mg/dl routinely. Patients, physicians, and parents should be alert to early clinical signs of toxicity. Chi...

27 A high dose of sodium salicylate temporarily induces tinnitus, mild hearing loss, and 28 possibly hyperacusis in humans and other animals. Salicylate has well-established effects on 29 cochlear function, primarily resulting in the moderate reduction of auditory input to the brain. 30 Despite decreased peripheral sensitivity and output, salicylate induces a paradoxical 31 enhancement of the s...